Deadly Fictional Diseases

by NDbportmanfan | created - 25 Jul 2017 | updated - 27 Jul 2017 | Public

Which of the following diseases seen in either television, video games, or film would you say is the worst of the worst?

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1. Rise of the Planet of the Apes (2011)

PG-13 | 105 min | Action, Drama, Sci-Fi

68 Metascore

A substance designed to help the brain repair itself gives advanced intelligence to a chimpanzee who leads an ape uprising.

Director: Rupert Wyatt | Stars: James Franco, Andy Serkis, Freida Pinto, Karin Konoval

Votes: 487,151 | Gross: $176.76M

The Simian Flu

2. Game of Thrones (2011–2019)

TV-MA | 57 min | Action, Adventure, Drama

Nine noble families fight for control over the lands of Westeros, while an ancient enemy returns after being dormant for millennia.

Stars: Emilia Clarke, Peter Dinklage, Kit Harington, Lena Headey

Votes: 1,677,025

Greyscale

3. Batman & Robin (1997)

PG-13 | 125 min | Action, Sci-Fi

28 Metascore

Batman and Robin try to keep their relationship together even as they must stop Mr. Freeze and Poison Ivy from freezing Gotham City.

Director: Joel Schumacher | Stars: Arnold Schwarzenegger, George Clooney, Chris O'Donnell, Uma Thurman

Votes: 227,770 | Gross: $107.33M

MacGregor's Syndrome

4. 28 Days Later... (2002)

R | 113 min | Drama, Horror, Sci-Fi

73 Metascore

Four weeks after a mysterious, incurable virus spreads throughout the UK, a handful of survivors try to find sanctuary.

Director: Danny Boyle | Stars: Cillian Murphy, Naomie Harris, Christopher Eccleston, Alex Palmer

Votes: 365,577 | Gross: $45.06M

Rage (Human Cortico-Deficiency Virus)

5. Osmosis Jones (2001)

PG | 95 min | Animation, Action, Adventure

57 Metascore

A policeman white blood cell, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.

Directors: Bobby Farrelly, Peter Farrelly | Stars: Laurence Fishburne, Chris Rock, David Hyde Pierce, Brandy Norwood

Votes: 31,381 | Gross: $13.60M

Red Death

6. Futurama (1999–2013)

TV-14 | 22 min | Animation, Comedy, Sci-Fi

Philip J. Fry, a pizza delivery boy, is accidentally frozen in 1999 and thawed out on New Year's Eve 2999.

Stars: Billy West, John DiMaggio, Katey Sagal, Tress MacNeille

Votes: 207,163

Bone-itis

7. Cabin Fever (2002)

R | 93 min | Horror

56 Metascore

Five college graduates rent a cabin in the woods and begin to fall victim to a horrifying flesh-eating virus, which attracts the unwanted attention of the homicidal locals.

Director: Eli Roth | Stars: Jordan Ladd, Rider Strong, James DeBello, Cerina Vincent

Votes: 72,486 | Gross: $21.16M

Flesh Eating Virus

8. Resident Evil (2002)

R | 100 min | Action, Horror, Sci-Fi

33 Metascore

A special military unit fights a powerful, out-of-control supercomputer and hundreds of scientists who have mutated into flesh-eating creatures after a laboratory accident.

Director: Paul W.S. Anderson | Stars: Milla Jovovich, Michelle Rodriguez, Ryan McCluskey, Oscar Pearce

Votes: 241,189 | Gross: $40.12M

T-Virus

9. Doctor Who (2005– )

TV-PG | 45 min | Adventure, Drama, Family

The further adventures in time and space of the alien adventurer known as the Doctor and their companions from planet Earth.

Stars: Jodie Whittaker, Peter Capaldi, Pearl Mackie, Matt Smith

Votes: 193,683

Bliss Virus

10. Dragon Ball Z (1996–2003)

TV-PG | 24 min | Animation, Action, Adventure

After learning that he is from another planet, a warrior named Goku and his friends are prompted to defend it from an onslaught of extraterrestrial enemies.

Stars: Doc Harris, Christopher Sabat, Scott McNeil, Sean Schemmel

Votes: 108,027

Heart Virus

11. Supernatural (2005–2020)

TV-14 | 44 min | Drama, Fantasy, Horror

Two brothers follow their father's footsteps as hunters, fighting evil supernatural beings of many kinds, including monsters, demons and gods that roam the earth.

Stars: Jared Padalecki, Jensen Ackles, Jim Beaver, Misha Collins

Votes: 373,756

Ghost Sickness

12. Blade Runner (1982)

R | 117 min | Action, Sci-Fi, Thriller

84 Metascore

A blade runner must pursue and terminate four replicants who stole a ship in space, and have returned to Earth to find their creator.

Director: Ridley Scott | Stars: Harrison Ford, Rutger Hauer, Sean Young, Edward James Olmos

Votes: 668,720 | Gross: $32.87M

Methuselah Syndrome

13. Doomsday (2008)

R | 105 min | Action, Sci-Fi, Thriller

51 Metascore

A futuristic action thriller where a team of people work to prevent a disaster threatening the future of the human race.

Director: Neil Marshall | Stars: Rhona Mitra, Bob Hoskins, Alexander Siddig, Caryn Peterson

Votes: 70,988 | Gross: $10.96M

Reaper Virus

14. The Last of Us (2013 Video Game)

M | Action, Adventure, Drama

In a hostile, post-pandemic world, Joel and Ellie, brought together by desperate circumstances, must rely on each other to survive a brutal journey across what remains of the United States.

Directors: Neil Druckmann, Bruce Straley | Stars: Troy Baker, Ashley Johnson, Hana Hayes, Jeffrey Pierce

Votes: 44,457

Cordyceps Brain Infection

15. Contagion (2011)

PG-13 | 106 min | Action, Drama, Thriller

70 Metascore

Healthcare professionals, government officials and everyday people find themselves in the midst of a pandemic as the CDC works to find a cure.

Director: Steven Soderbergh | Stars: Matt Damon, Kate Winslet, Jude Law, Gwyneth Paltrow

Votes: 267,212 | Gross: $75.66M

MEV-1

16. The Andromeda Strain (1971)

G | 131 min | Mystery, Sci-Fi, Thriller

60 Metascore

A team of top scientists work feverishly in a secret, state-of-the-art laboratory to discover what has killed the citizens of a small town and learn how this deadly contagion can be stopped.

Director: Robert Wise | Stars: James Olson, Arthur Hill, David Wayne, Kate Reid

Votes: 32,534 | Gross: $3.42M

The Andromeda Strain

17. Halo: Combat Evolved (2001 Video Game)

M | Action, Adventure, Mystery

Super-soldier John-117, Master Chief of the United Nations Space Command, must battle a genocidal alien race known as the Covenant following his violent crash-landing on Halo, an ancient and mysterious ring-world.

Director: Jason Jones | Stars: Jen Taylor, Pete Stacker, Tim Dadabo, Steve Downes

Votes: 9,500

Flood Parasite

18. Deus Ex (2000 Video Game)

M | Action, Mystery, Sci-Fi

In a dark cyberpunk future where poverty, disease, oppression and terrorism are widespread, J.C. Denton, a new cybernetically-enhanced special agent, finds evidence of a massive conspiracy when his brother, also an agent, goes rogue.

Director: Warren Spector | Stars: Jay Anthony Franke, Brent Anderson, Ralph Barbagallo, Chad Bannon

Votes: 2,803

Gray Death

19. Outbreak (1995)

R | 127 min | Action, Drama, Thriller

64 Metascore

Army doctors struggle to find a cure for a deadly virus spreading throughout a California town that was brought to America by an African monkey.

Director: Wolfgang Petersen | Stars: Dustin Hoffman, Rene Russo, Morgan Freeman, Kevin Spacey

Votes: 115,540 | Gross: $67.82M

Motaba

20. Mimic (1997)

R | 105 min | Horror, Sci-Fi

55 Metascore

Three years ago, entomologist Dr. Susan Tyler genetically created an insect to kill cockroaches carrying a virulent disease. Now, the insects are out to destroy their only predator, mankind.

Director: Guillermo del Toro | Stars: Mira Sorvino, Jeremy Northam, Alexander Goodwin, Giancarlo Giannini

Votes: 44,660 | Gross: $25.48M

Strickler’s Disease

21. Dreamcatcher (2003)

R | 134 min | Drama, Horror, Sci-Fi

35 Metascore

Friends on a camping trip discover that the town they're vacationing in is being plagued in an unusual fashion by parasitic aliens from outer space.

Director: Lawrence Kasdan | Stars: Morgan Freeman, Thomas Jane, Jason Lee, Damian Lewis

Votes: 87,136 | Gross: $33.72M

The Ripley

22. Gears of War (2006 Video Game)

M | Action, Adventure, Fantasy

Mankind's desperate struggle for survival against a the Locust Horde, a nightmarish race of creatures that surface from the planet's core.

Director: Mo Davoudian | Stars: John DiMaggio, Carlos Ferro, Lester Speight, Fred Tatasciore

Votes: 7,892

Rust Lung

23. Carnosaur (1993)

R | 83 min | Horror, Sci-Fi

A genetically manipulated and very hungry dinosaur escapes from a bioengineering company and reeks havoc on the local desert town. A security guard and a girl environmentalist try to stop both it and the company's doomsday bioweapon.

Directors: Adam Simon, Darren Moloney | Stars: Diane Ladd, Raphael Sbarge, Jennifer Runyon, Harrison Page

Votes: 3,584 | Gross: $1.75M

Carnosaur Virus

24. Johnny Mnemonic (1995)

R | 96 min | Action, Drama, Sci-Fi

A data courier, literally carrying a data package inside his head, must deliver it before he dies from the burden or is killed by the Yakuza.

Director: Robert Longo | Stars: Keanu Reeves, Dolph Lundgren, Dina Meyer, Ice-T

Votes: 64,672 | Gross: $19.08M

Nerve Attenuation Syndrome

25. Repo! The Genetic Opera (2008)

R | 98 min | Horror, Musical, Sci-Fi

32 Metascore

A worldwide epidemic encourages a biotech company to launch an organ-financing program similar in nature to a standard car loan. The repossession clause is a killer, however.

Director: Darren Lynn Bousman | Stars: Paul Sorvino, Anthony Head, Alexa PenaVega, Sarah Brightman

Votes: 23,058 | Gross: $0.14M

Synaptic/Neuro Overstimulation Syndrome

26. Ultraviolet (2006)

PG-13 | 88 min | Action, Sci-Fi

18 Metascore

A beautiful hæmophage infected with a virus that gives her superhuman powers has to protect a boy in a futuristic world, who is thought to be carrying antigens that would destroy all hæmophages.

Director: Kurt Wimmer | Stars: Milla Jovovich, Cameron Bright, Nick Chinlund, Sebastien Andrieu

Votes: 78,301 | Gross: $18.50M

Hemoglophagia

27. The Walking Dead (2010– )

TV-14 | 44 min | Drama, Horror, Thriller

Sheriff Deputy Rick Grimes wakes up from a coma to learn the world is in ruins and must lead a group of survivors to stay alive.

Stars: Andrew Lincoln, Norman Reedus, Melissa McBride, Danai Gurira

Votes: 826,380

TS-19

28. Fallout 3 (2008 Video Game)

M | Action, Adventure, Crime

Centuries following nuclear war, a teen leaves the safety of an underground vault in order to find their father, who left in hopes of creating a water purifier.

Director: Todd Howard | Stars: Liam Neeson, Malcolm McDowell, Ron Perlman, Odette Annable

Votes: 17,007

Forced Evolutionary Virus

29. Red Dwarf (1988– )

TV-14 | 30 min | Adventure, Comedy, Sci-Fi

The adventures of the last human alive and his friends, stranded three million years into deep space on the mining ship Red Dwarf.

Stars: Chris Barrie, Craig Charles, Danny John-Jules, Robert Llewellyn

Votes: 31,917

Space Mumps

30. The Last Ship (2014–2018)

TV-14 | 60 min | Action, Drama, Sci-Fi

The crew of a naval destroyer is forced to confront the reality of a new existence when a pandemic kills off most of the earth's population.

Stars: Eric Dane, Adam Baldwin, Charles Parnell, Travis Van Winkle

Votes: 52,934

Red Flu

31. Babylon 5 (1993–1998)

TV-PG | 45 min | Action, Adventure, Drama

In the mid 23rd Century, the Earth Alliance space station Babylon 5, located in neutral territory, is a major focal point for political intrigue, racial tensions and various wars over the course of five years.

Stars: Mira Furlan, Richard Biggs, Stephen Furst, Andreas Katsulas

Votes: 27,092

Drafa Plague

32. Firefly (2002–2003)

TV-14 | 44 min | Adventure, Drama, Sci-Fi

Five hundred years in the future, a renegade crew aboard a small spacecraft tries to survive as they travel the unknown parts of the galaxy and evade warring factions as well as authority agents out to get them.

Stars: Nathan Fillion, Gina Torres, Alan Tudyk, Morena Baccarin

Votes: 236,627

Bowden's Malady

33. Star Trek: The Next Generation (1987–1994)

TV-PG | 44 min | Action, Adventure, Mystery

Set almost 100 years after Captain Kirk's five-year mission, a new generation of Starfleet officers set off in the U.S.S. Enterprise-D on their own mission to go where no one has gone before.

Stars: Patrick Stewart, Brent Spiner, Jonathan Frakes, LeVar Burton

Votes: 94,682

Barclay's Protomorphosis Syndrome

34. Dragon Age: Origins (2009 Video Game)

M | Action, Adventure, Fantasy

After four hundred years since the last Blight, a new Archdemon seeks to destroy the land of Ferelden. It is up to the player - as one of the remaining Grey Wardens - to unite the divided armies of Ferelden and save humanity.

Director: Dan Tudge | Stars: Steve Valentine, Peter Renaday, Kate Mulgrew, Tim Curry

Votes: 6,948

Blight Disease

35. The X-Files (1993–2018)

TV-14 | 45 min | Crime, Drama, Mystery

Two F.B.I. Agents, Fox Mulder the believer and Dana Scully the skeptic, investigate the strange and unexplained, while hidden forces work to impede their efforts.

Stars: David Duchovny, Gillian Anderson, Mitch Pileggi, William B. Davis

Votes: 191,775

Purity



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