Deadly Fictional Diseasesby NDbportmanfan | created - 25 Jul 2017 | updated - 27 Jul 2017 | Public
Which of the following diseases seen in either television, video games, or film would you say is the worst of the worst?
- Instant Watch Options
- Movies or TV
- IMDb Rating
- In Theaters
- On TV
- Release Year
1. Rise of the Planet of the Apes (2011)
PG-13 | 105 min | Action, Drama, Sci-Fi
A substance designed to help the brain repair itself gives advanced intelligence to a chimpanzee who leads an ape uprising.
Votes: 487,151 | Gross: $176.76M
The Simian Flu
2. Game of Thrones (2011–2019)
TV-MA | 57 min | Action, Adventure, Drama
Nine noble families fight for control over the lands of Westeros, while an ancient enemy returns after being dormant for millennia.
3. Batman & Robin (1997)
PG-13 | 125 min | Action, Sci-Fi
Batman and Robin try to keep their relationship together even as they must stop Mr. Freeze and Poison Ivy from freezing Gotham City.
Votes: 227,770 | Gross: $107.33M
4. 28 Days Later... (2002)
R | 113 min | Drama, Horror, Sci-Fi
Four weeks after a mysterious, incurable virus spreads throughout the UK, a handful of survivors try to find sanctuary.
Votes: 365,577 | Gross: $45.06M
Rage (Human Cortico-Deficiency Virus)
5. Osmosis Jones (2001)
PG | 95 min | Animation, Action, Adventure
A policeman white blood cell, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
Votes: 31,381 | Gross: $13.60M
6. Futurama (1999–2013)
TV-14 | 22 min | Animation, Comedy, Sci-Fi
Philip J. Fry, a pizza delivery boy, is accidentally frozen in 1999 and thawed out on New Year's Eve 2999.
7. Cabin Fever (2002)
R | 93 min | Horror
Five college graduates rent a cabin in the woods and begin to fall victim to a horrifying flesh-eating virus, which attracts the unwanted attention of the homicidal locals.
Votes: 72,486 | Gross: $21.16M
Flesh Eating Virus
8. Resident Evil (2002)
R | 100 min | Action, Horror, Sci-Fi
A special military unit fights a powerful, out-of-control supercomputer and hundreds of scientists who have mutated into flesh-eating creatures after a laboratory accident.
Votes: 241,189 | Gross: $40.12M
9. Doctor Who (2005– )
TV-PG | 45 min | Adventure, Drama, Family
The further adventures in time and space of the alien adventurer known as the Doctor and their companions from planet Earth.
10. Dragon Ball Z (1996–2003)
TV-PG | 24 min | Animation, Action, Adventure
After learning that he is from another planet, a warrior named Goku and his friends are prompted to defend it from an onslaught of extraterrestrial enemies.
11. Supernatural (2005–2020)
TV-14 | 44 min | Drama, Fantasy, Horror
Two brothers follow their father's footsteps as hunters, fighting evil supernatural beings of many kinds, including monsters, demons and gods that roam the earth.
12. Blade Runner (1982)
R | 117 min | Action, Sci-Fi, Thriller
A blade runner must pursue and terminate four replicants who stole a ship in space, and have returned to Earth to find their creator.
Votes: 668,720 | Gross: $32.87M
13. Doomsday (2008)
R | 105 min | Action, Sci-Fi, Thriller
A futuristic action thriller where a team of people work to prevent a disaster threatening the future of the human race.
Votes: 70,988 | Gross: $10.96M
14. The Last of Us (2013 Video Game)
M | Action, Adventure, Drama
In a hostile, post-pandemic world, Joel and Ellie, brought together by desperate circumstances, must rely on each other to survive a brutal journey across what remains of the United States.
Cordyceps Brain Infection
15. Contagion (2011)
PG-13 | 106 min | Action, Drama, Thriller
Healthcare professionals, government officials and everyday people find themselves in the midst of a pandemic as the CDC works to find a cure.
Votes: 267,212 | Gross: $75.66M
16. The Andromeda Strain (1971)
G | 131 min | Mystery, Sci-Fi, Thriller
A team of top scientists work feverishly in a secret, state-of-the-art laboratory to discover what has killed the citizens of a small town and learn how this deadly contagion can be stopped.
Votes: 32,534 | Gross: $3.42M
The Andromeda Strain
17. Halo: Combat Evolved (2001 Video Game)
M | Action, Adventure, Mystery
Super-soldier John-117, Master Chief of the United Nations Space Command, must battle a genocidal alien race known as the Covenant following his violent crash-landing on Halo, an ancient and mysterious ring-world.
18. Deus Ex (2000 Video Game)
M | Action, Mystery, Sci-Fi
In a dark cyberpunk future where poverty, disease, oppression and terrorism are widespread, J.C. Denton, a new cybernetically-enhanced special agent, finds evidence of a massive conspiracy when his brother, also an agent, goes rogue.
19. Outbreak (1995)
R | 127 min | Action, Drama, Thriller
Army doctors struggle to find a cure for a deadly virus spreading throughout a California town that was brought to America by an African monkey.
Votes: 115,540 | Gross: $67.82M
20. Mimic (1997)
R | 105 min | Horror, Sci-Fi
Three years ago, entomologist Dr. Susan Tyler genetically created an insect to kill cockroaches carrying a virulent disease. Now, the insects are out to destroy their only predator, mankind.
Votes: 44,660 | Gross: $25.48M
21. Dreamcatcher (2003)
R | 134 min | Drama, Horror, Sci-Fi
Friends on a camping trip discover that the town they're vacationing in is being plagued in an unusual fashion by parasitic aliens from outer space.
Votes: 87,136 | Gross: $33.72M
22. Gears of War (2006 Video Game)
M | Action, Adventure, Fantasy
Mankind's desperate struggle for survival against a the Locust Horde, a nightmarish race of creatures that surface from the planet's core.
23. Carnosaur (1993)
R | 83 min | Horror, Sci-Fi
A genetically manipulated and very hungry dinosaur escapes from a bioengineering company and reeks havoc on the local desert town. A security guard and a girl environmentalist try to stop both it and the company's doomsday bioweapon.
Votes: 3,584 | Gross: $1.75M
24. Johnny Mnemonic (1995)
R | 96 min | Action, Drama, Sci-Fi
A data courier, literally carrying a data package inside his head, must deliver it before he dies from the burden or is killed by the Yakuza.
Votes: 64,672 | Gross: $19.08M
Nerve Attenuation Syndrome
25. Repo! The Genetic Opera (2008)
R | 98 min | Horror, Musical, Sci-Fi
A worldwide epidemic encourages a biotech company to launch an organ-financing program similar in nature to a standard car loan. The repossession clause is a killer, however.
Votes: 23,058 | Gross: $0.14M
Synaptic/Neuro Overstimulation Syndrome
26. Ultraviolet (2006)
PG-13 | 88 min | Action, Sci-Fi
A beautiful hæmophage infected with a virus that gives her superhuman powers has to protect a boy in a futuristic world, who is thought to be carrying antigens that would destroy all hæmophages.
Votes: 78,301 | Gross: $18.50M
27. The Walking Dead (2010– )
TV-14 | 44 min | Drama, Horror, Thriller
Sheriff Deputy Rick Grimes wakes up from a coma to learn the world is in ruins and must lead a group of survivors to stay alive.
28. Fallout 3 (2008 Video Game)
M | Action, Adventure, Crime
Centuries following nuclear war, a teen leaves the safety of an underground vault in order to find their father, who left in hopes of creating a water purifier.
Forced Evolutionary Virus
29. Red Dwarf (1988– )
TV-14 | 30 min | Adventure, Comedy, Sci-Fi
The adventures of the last human alive and his friends, stranded three million years into deep space on the mining ship Red Dwarf.
30. The Last Ship (2014–2018)
TV-14 | 60 min | Action, Drama, Sci-Fi
The crew of a naval destroyer is forced to confront the reality of a new existence when a pandemic kills off most of the earth's population.
31. Babylon 5 (1993–1998)
TV-PG | 45 min | Action, Adventure, Drama
In the mid 23rd Century, the Earth Alliance space station Babylon 5, located in neutral territory, is a major focal point for political intrigue, racial tensions and various wars over the course of five years.
32. Firefly (2002–2003)
TV-14 | 44 min | Adventure, Drama, Sci-Fi
Five hundred years in the future, a renegade crew aboard a small spacecraft tries to survive as they travel the unknown parts of the galaxy and evade warring factions as well as authority agents out to get them.
33. Star Trek: The Next Generation (1987–1994)
TV-PG | 44 min | Action, Adventure, Mystery
Set almost 100 years after Captain Kirk's five-year mission, a new generation of Starfleet officers set off in the U.S.S. Enterprise-D on their own mission to go where no one has gone before.
Barclay's Protomorphosis Syndrome
34. Dragon Age: Origins (2009 Video Game)
M | Action, Adventure, Fantasy
After four hundred years since the last Blight, a new Archdemon seeks to destroy the land of Ferelden. It is up to the player - as one of the remaining Grey Wardens - to unite the divided armies of Ferelden and save humanity.
35. The X-Files (1993–2018)
TV-14 | 45 min | Crime, Drama, Mystery
Two F.B.I. Agents, Fox Mulder the believer and Dana Scully the skeptic, investigate the strange and unexplained, while hidden forces work to impede their efforts.