- Despite playing the "dumb girl" in movies and TV, she actually graduated with a 4.0 GPA and was considered gifted in intelligence and arts.
- Requested that her character Abby Morgan be written out of Dawson's Creek (1998) as her boyfriend at the time was living in New York and she didn't like being in Wilmington, North Carolina, where the show filmed.
- Monica auditioned for acceptance into LaGuardia High School of Performing Arts, made famous by Fame (1980) and its follow-up TV series Fame (1982). She was accepted into both the vocal and dramatic arts department, and chose drama.
- Her character, Rachel Lindquist, on the TV series, Undeclared (2001), was based on her.
- Gives Kathy Bates and Jennifer Jason Leigh credit for her still being in the acting business.
- During the New York run of the controversial film Ripe (1996), stars Monica Keena and Daisy Eagan would regularly attend screenings to view the audience's reactions and meet with them afterward.
- Claims she is anti doing anything physical.
- Says that her film Ripe (1996) is the movie that she is most proud of.
- Has a fear of the dark.
- Only spent 2 1/2 years in her High School because she was constantly filming.
- Her favorite actress is Judy Garland and her favorite movie is The Wizard of Oz (1939).
- She took her grandmother to the Freddy vs. Jason (2003) premiere.
- Enjoys writing and is an English major.
- Posed for Maxim, Stuff Magazine and FHM.
- Was raised in Brooklyn, New York, and still lives in the city.
- Irish-American.
- Has been rollerskating and skatebording since a young child.
- Is friends with actress Meredith Monroe.
- Did a screen test with Al Pacino.
- Her parents enrolled her in prep schools to keep her sheltered from the "wild life", little did they know that would lead her on a string of rebellion through her early teens.
- Favorite shows are The Simpsons (1989) and Charmed (1998).
- The school she attended in Brooklyn Heights, Saint Ann's, was once named #1 school in the country by The Wall Street Journal.
- Is good friends with actor Vincent Kartheiser.
- Daughter of William B. "Bill" Keena Jr., of Irish descent, and wife Mary Catherine ..., was raised by her mother and maternal grandmother.
- Monica has always found an outlet for her creativity. As a child, she immersed herself in classes, determined to perfect her craft in drawing, painting, singing and dance
- Has taken writing classes.
- Sister Samantha is two years older.
- Won an award in 7th grade for reciting the poem "Casey at the Bat".
- As a young child, she was always drawing, painting, dancing and singing.
- She has performed at the Heights Players in Brooklyn in Little Women (as Beth) and The Lion, The Witch and The Wardrobe as Lucy (alongside actor Tim Realbuto).
- Her own teenage friendships suffered when she traveled for acting work.
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