- Creater of the syndicated comic strip "The Far Side", which featured surreal humor.
- Creator of "The Far Side" which debuted in the San Francisco Chronicle on 1 January 1980. He retired from daily panels on 1 January 1995, at which time "The Far Side" was being seen in 1,900 daily and Sunday newspapers worldwide.
- Has an Owl Louse named after him: Strigiphilus garylarsoni.
- One of his most famous "Far Side" comics portrayed a video store in Hell that only stocked copies of Ishtar (1987). Larson later admitted he had not actually seen the film when he drew the comic, and later caught it on an airplane and admitted he actually enjoyed it.
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