- Was offered the part of Kat in Tenet (2020) without an audition, but insisted on doing one anyway. It was really important for her to know that she could do what Christopher Nolan was looking for, and according to the director she came in and blew everyone away.
- Parents were both professional ballet dancers, and she always assumed she would go into the family business. However, at the age of 12 she was taller than all of her teachers. She began concentrating on contemporary dance instead, and then somewhere along the line fell in love with acting and applied to drama school.
- Reportedly beat out Charlize Theron and fellow Aussie Rose Byrne for her role in The Man from U.N.C.L.E. (2015).
- Her first Hollywood role and second feature film was The Great Gatsby (2013), although it was filmed in her home country of Australia. Her first time coming to America would be to screen test with Tobey Maguire for director Baz Luhrmann.
- Upon graduating from high school at age 17, she had to decide between studying drama at the University of Melbourne or attending law school on an academic scholarship, having already gotten in. She said that her parents were "rightfully concerned" when she decided to forgo law school and study acting instead.
- Her performance as golfer Jordan Baker in Baz Luhrmann's The Great Gatsby (2013) was ranked #32 in IndieWire's 'The 50 Best Movie Performances of the Decade'. [2019].
- Member of the Academy of Motion Picture Arts and Sciences (AMPAS) since 2018.
- In 2015, she was honored as the breakthrough star of the year at the Australians in Film awards gala, following her roles in The Man from U.N.C.L.E. (2015), Macbeth (2015), and Everest (2015). Previous recipients of the Breakthrough Award include Chris Hemsworth, Margot Robbie, Joel Edgerton, and Mia Wasikowska.
- Favorite movies growing up were Matilda (1996) and Hook (1991). She has also said that she was obsessed with the American animated superhero television series Captain Planet and the Planeteers (1990) and would pretend to be those characters.
- She was added to the cast of the sci-fi movie Valerian and the City of a Thousand Planets (2017) in an undisclosed voiceover role a month and a half before its release in theaters. The role was eventually revealed to be Emperor Haban-Limaï. French model turned actor Aymeline Valade did the motion capture for the character.
- Had no driving experience before being cast in The Man from U.N.C.L.E. (2015).
- Her performance in the all-female heist film Widows (2018) was ranked #8 in IndieWire's 'The 16 Best Film Performances by Actresses in 2018'.
- Was nominated for the 2014 Helpmann Award for Best Female Actor in a Supporting Role in a Play for her stage performance in The Sydney Theatre Company's production of Jean Genet's "The Maids" directed by Andrew Upton.
- Made her feature film debut in director Stephan Elliott's Australian wedding comedy A Few Best Men (2011), in a small role as a secretary. It was her first role after graduating from drama school. She was only 21 when it premiered at the Mill Valley Film Festival in San Rafael, California on 14 October 14 2011.
- Was awarded the Trophée Chopard at the 2018 Cannes Film Festival, alongside actor Joe Alwyn. The Chopard Trophy is awarded by a jury of professionals to two young actors in order to recognize and encourage their careers. Founded in 2001, it has been presented every year since during the Cannes Film Festival.
- Was originally cast as Christina Braithwhite in the horror series Lovecraft Country (2020), but had to drop out due to scheduling conflicts with Tenet (2020). The role later went to fellow Australian actress Abbey Lee.
- Appeared on the cover of Vanity Fair's 25th Annual Hollywood Issue, alongside Nicholas Hoult, Rami Malek, Chadwick Boseman, Saoirse Ronan, Tessa Thompson, Henry Golding, Yalitza Aparicio, Regina King, Timothée Chalamet, and John David Washington.
- She was on the shortlist of actresses who were in the running to play the lead female role in the Harry Potter spin-off movie Fantastic Beasts and Where to Find Them (2016), along with Katherine Waterston and Kate Upton. The role went to Waterston.
- Debicki was the 14th recipient of the Women in Film 'Max Mara Face of the Future Award'. She was honored at the 2019 Women in Film Awards on June 12th at The Beverly Hilton in Beverly Hills, California. (2019)
- Was originally cast as Una in The Dressmaker (2015), joining the cast in early May 2014, however, she dropped out that October to play the lead in the Australian television series The Kettering Incident (2016). Interestingly, she was actually replaced in the film by one of her co-stars from the series, Sacha Horler.
- Is the eldest of three children. She has a younger sister and brother.
- She auditioned for the lead female role in Gemini Man (2019), along with Tatiana Maslany. Actress Mary Elizabeth Winstead eventually got the part.
- Her godmother is actress Haydn Gwynne.
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