Kuenssberg, who is currently business editor at ITV News, will start work on the programme in mid-February 2014 as chief correspondent. She will also join the regular Newsnight presenting team alongside Jeremy Paxman, Kirsty Wark, Gavin Esler and Emily Maitlis.
"Working with the team at ITV News to cover the intense challenges faced by business, families and the wider economy has been a real privilege and I've really enjoyed the last couple of years," said Kuenssberg.
"But I'm truly delighted to be joining a reinvigorated Newsnight both to present and report at such an exciting time. It's been a long-held ambition of mine to work full-time on the programme and I can't wait to get started."
Kuenssberg returns to the BBC having originally joined the organisation in the year 2000.
She departed for ITV in 2011, after a stint as the BBC News Channel's chief political correspondent.