The New York Times reported that his son said he died of bone marrow cancer.
After getting his start in television, Grodin graduated to both leading and character roles in motion pictures, usually portraying the exasperated urban neurotic. His dry, understated sense of humor also made him a perfect talkshow guest, and later, host of his own cable show. Grodin also wrote plays and books.
The wry 1972 comedy “The Heartbreak Kid,” written by Neil Simon and directed by Elaine May, highlighted Grodin’s trademark neurotic befuddlement, and won him a Golden Globe nomination. But it was one of the few successful films in his career in which he was center stage.