Naturally, people will have different views about the quality of the series, and the recent Grey's Anatomy Season 17 divided fans like no other.
One fan referred to the season as "trash" but maintained that they loved the show.
Pompeo took notice of the Tweet and appreciated that the fan gave feedback on the show.
"All good!" Pompeo wrote.
"Seventeen seasons we can't please everyone all the time … it's definitely not easy keeping it going and keeping it great… I get it…thanks for checking it out anyway… and thanks for your feedback it matters …sending you love."
As is the norm with social media, people have different views, and some other fans did not take too kindly to how the fan characterized the season.
"But why is someone saying they didn't like something bad? It's literally been on for two decades!