Alex and Meredith's friendship on Grey's Anatomy had a rocky start, but the pair grew to love and support each other, and eventually became best friends. Up until Alex's sudden departure in season 16, they bonded with each other through the similarities they shared, and the experiences they had gone through together.
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However, along the way there were many times where Alex and Meredith clashed with each other, or went behind the other's back. Whilst they would always reconcile, some of the things they did to each other were detrimental and sometimes had long-lasting effects.