- A young F.B.I. cadet must receive the help of an incarcerated and manipulative cannibal killer to help catch another serial killer, a madman who skins his victims.
- F.B.I. trainee Clarice Starling (Jodie Foster) works hard to advance her career, while trying to hide or put behind her West Virginia roots, of which if some knew, would automatically classify her as being backward or white trash. After graduation, she aspires to work in the agency's Behavioral Science Unit under the leadership of Jack Crawford (Scott Glenn). While she is still a trainee, Crawford asks her to question Dr. Hannibal Lecter (Sir Anthony Hopkins), a psychiatrist imprisoned, thus far, for eight years in maximum security isolation for being a serial killer who cannibalized his victims. Clarice is able to figure out the assignment is to pick Lecter's brains to help them solve another serial murder case, that of someone coined by the media as "Buffalo Bill" (Ted Levine), who has so far killed five victims, all located in the eastern U.S., all young women, who are slightly overweight (especially around the hips), all who were drowned in natural bodies of water, and all who were stripped of large swaths of skin. She also figures that Crawford chose her, as a woman, to be able to trigger some emotional response from Lecter. After speaking to Lecter for the first time, she realizes that everything with him will be a psychological game, with her often having to read between the very cryptic lines he provides. She has to decide how much she will play along, as his request in return for talking to him is to expose herself emotionally to him. The case takes a more dire turn when a sixth victim is discovered, this one from who they are able to retrieve a key piece of evidence, if Lecter is being forthright as to its meaning. A potential seventh victim is high profile Catherine Martin (Brooke Smith), the daughter of Senator Ruth Martin (Diane Baker), which places greater scrutiny on the case as they search for a hopefully still alive Catherine. Who may factor into what happens is Dr. Frederick Chilton (Anthony Heald), the warden at the prison, an opportunist who sees the higher profile with Catherine, meaning a higher profile for himself if he can insert himself successfully into the proceedings.—Huggo
- Perplexed by a string of grisly murders elaborately executed by the elusive mass-killer nicknamed "Buffalo Bill", the vulnerable and untried F.B.I. trainee, Clarice Starling, is assigned by the Special Agent, Jack Crawford, to assist in the manhunt. Hoping to attain a clearer perception of the psychopathic serial killer's modus operandi, the young investigator reluctantly accepts the help of another hideous monster: the brilliant psychiatrist and cannibalistic mass-murderer, Dr Hannibal Lecter. Now, with every visit to the manipulative doctor's heavily reinforced prison cell, Clarice delves just a little bit deeper into the dark mind of a homicidal maniac; however, how far is she willing to go to unearth pure evil?—Nick Riganas
- Young F.B.I. trainee Clarice Starling (Jodie Foster) is assigned to help find a missing woman to save her from a psychopathic serial killer (Ted Levine) who skins his victims. Clarice attempts to gain a better insight into the twisted mind of the killer by talking to another psychopath: Dr. Hannibal Lecter (Sir Anthony Hopkins), who used to be a respected psychiatrist. F.B.I. Special Agent Jack Crawford (Scott Glenn) believes that Lecter, who is also a very powerful and clever mind manipulator, has the answers to their questions and can help locate the killer. However, Clarice must first gain Lecter's confidence before the inmate will give away any information.—Sami Al-Taher <staher2000@yahoo.com>
- Clarice Starling (Jodie Foster), a young intelligent F.B.I. trainee, has been sent to the Baltimore state hospital for the criminally insane to interview an inmate, Dr. Hannibal "the cannibal" Lecter (Sir Anthony Hopkins), a brilliant renowned psychiatrist turned infamous psychopathic serial killer. She must match wits with Lecter, who has the darkest of all minds, and trust him to give her clues in the search for "Buffalo Bill" (Ted Levine), a nickname given to a loose, unknown, unstoppable psychopathic serial killer.—ahmetkozan
- Promising FBI Academy student Clarice Starling is pulled from her training at the FBI Training Facility at Quantico, Virginia by Jack Crawford of the FBI's Behavioral Science Unit, who tasks her with presenting a VICAP questionnaire to the notorious Dr. Hannibal Lecter, a brilliant forensic psychiatrist and incarcerated cannibalistic serial murderer. After learning the assignment relates to the pursuit of vicious serial killer Buffalo Bill, Starling travels to the Baltimore State Hospital for the Criminally Insane and is led by Dr. Frederick Chilton to Hannibal Lecter, a sophisticated, cultured man restrained behind thick glass panels and windowless stone walls. Although initially pleasant and courteous, Lecter grows impatient with Starling's attempts at "dissecting" him and viciously rebuffs her. As Starling departs, another patient flings fresh semen onto her face, enraging Lecter who calls Starling back and offers a riddle containing information about a former patient. The solved riddle leads to a rent-a-storage lot where the severed head of Benjamin Raspail is found. Starling returns to Lecter, who links Raspail to Buffalo Bill and who offers to help profile Buffalo Bill if he is transferred to a facility far from the venomous, careerist Dr. Chilton.
Hours and miles away, Buffalo Bill abducts Catherine Martin, the daughter of United States Senator Ruth Martin. Starling is pulled from Quantico and accompanies Crawford to West Virginia, where the body of Bill's most recently-discovered victim resides. In the plane taking them to the town, Crawford asks Starling what she sees in the file on Buffalo Bill. She says that Bill is a male, definitely white and that he's getting better at his work since he's "developed a taste for it". At the coroner's office, Starling helps perform the autopsy and extracts the chrysalis of a Death's-head Hawkmoth from the victim's throat. When the victim is turned over for further examination, they find that two large, diamond-shaped strips of flesh have been flayed from her body. Having already spoken to Lecter about how Bill flays his victims, this detail is recorded by Starling.
At Quantico, as news of Catherine Martin's abduction sweeps the country, Crawford authorizes Starling to offer Hannibal Lecter a fake deal promising a prison transfer if he provides information that helps profile Buffalo Bill and rescue Catherine Martin. Instead, Lecter begins a game of "quid pro quo" with Starling, offering comprehensive clues and insights about Buffalo Bill in exchange for events from Starling's traumatic childhood. Unaware to both Starling and Lecter, Dr. Frederick Chilton tapes the conversation and after revealing Starling's deal as a sham, offers to transfer Lecter in exchange for a deal of his own making, one that will make Chilton out as a hero for identifying and tracking down Buffalo Bill. Lecter agrees and following a flight to Tennessee reveals Buffalo Bill's real name, physical description and past address to Senator Martin and her entourage of FBI agents and Justice Department officials. He also insults Martin openly, asking about her breastfeeding of her daughter. Martin orders Lecter back to Baltimore when he spills Buffalo Bill's identity information.
As the manhunt begins, Starling travels to Lecter's special cell in a local Tennessee courthouse, where she confronts him about the false information he gave the Senator. Lecter refuses Starling's pleas and demands she finish her story surrounding her worst childhood memory. After recounting her arrival at a relative's farm, the horror of discovering their lamb slaughterhouse and her fruitless attempts at rescuing the lambs -- they screamed as they were being slaughtered, a memory that has haunted Starling her whole life -- Lecter rebuffs her, leaving her with her case file before she is escorted out of the building by security guards. As she reaches for the file, he touches one of her fingers.
Later that evening, Lecter escapes from his cell, his two minders distracted by having to move his sketches and tricking them into approaching him too closely. The local police storm the floor, discovering one guard barely alive and the other disemboweled and strung up on the bars of Lecter's cage like an angel. Paramedics transport the survivor to an ambulance and speed off while a SWAT team searches the building for Lecter. As the team discover a body on top of the elevator car, the survivor in the ambulance peels off his own face, revealing Lecter in disguise, who kills the paramedics and escapes to the airport.
After being notified of Lecter's escape, Starling pores over her case file, analyzing Lecter's annotations before realizing that the first victim, Frederica Bimmel, knew Bill in real life before he killed her. Starling travels to Bimmel's hometown and discovers that Bimmel was a tailor and has dresses with templates identical to the patches of skin removed from Buffalo Bill's victims. Realizing that Buffalo Bill is a tailor fashioning a "woman suit" of real skin, she telephones Crawford, who is already on the way to make an arrest, having cross-referenced Lecter's notes with Johns Hopkins Hospital and finding a man named Jame Gumb. Crawford instructs Starling to continue interviewing Bimmel's friends while he leads a SWAT team to Gumb's business address in Calumet City, Illinois. Starling's interviews lead to the house of "Jack Gordon," whom Starling soon realizes is actually Gumb, and draws her weapon just as Gumb disappears into his basement. Starling pursues him in the basement, which consists of several rooms, discovering a screaming Catherine Martin in the dry well. The lights in the basement suddenly go out, leaving her in complete darkness. Gumb stalks Starling in the dark with night vision goggles and prepares to shoot her when Starling, hearing the clicks of his drawing back the hammer on his revolver, swivels around and shoots Gumb dead.
Days later at the FBI Academy graduation party, Starling receives a phone call from Hannibal Lecter, now in the Bahamas. As Lecter assures Starling he has no plans to pursue her, he excuses himself from the phone call, remarking that he's "having an old friend for dinner" before hanging up and following Dr Chilton through the streets of the village.
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