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The series never follows a specific timeline. For example in season 6 Lisa tells Tia that Tamera has made it without her for 12 years, Implying that the girls have known each other for 6 years(the actual duration of the show). However, when the girls meet they say that they were born November 1979 making them 15 going on 16 y/o by the time the show premieres in 1994. If you follow the narrative of the show the girls really have known each other for 3 years since they met until their freshman year of college (timeline in the show). This is made clear when they celebrate their 16th birthday in season 1 and later their 17th birthday in season 5. Making seasons 1-5 set in the span of a year. After that everything starts making sense. They graduate high school by the end of season five, start college by the beginning of season six and then in the second to last episode of the series the girls are finishing their freshman year of college and making plans for the summer, etc.
Marques Houston's reason for leaving the show was due to the fact that his mother died.
Jackée Harry and Tim Reid would later play husband and wife in the Lifetime television movie My Christmas Inn (2018) which featured Tia Mowry who played their daughter in the film.
At the beginning of the show's run, a beauty mark was drawn on Tia's cheek to match the one naturally on Tamera's cheek.
The twins' real-life brother Tahj Mowry guest starred in three different episodes, each time as a different character.
Celebrities who've made appearances throughout the program include Kenan Thompson, Kel Mitchell, Sherman Hemsley, Daphne Maxwell Reid, Kobe Bryant, Tyrese, Mary-Kate and Ashley Olsen, Lisa Leslie, Milton Berle, Boyz II Men, Molly Shannon, and Brittany Murphy.