Ollie must fight for Jac's support when Matteo pitches against him. Dom tries to keep his relationship with Isaac a secret from his parents. Cameron fights his feelings for Morven on his last shift.
Fletch's own fortunes take an unimaginable turn. Sacha suspects Essie and Raf are hiding their relationship from him. Matteo tries to win Jac over romantically.
Mo is forced to choose between Sweden and her profession. Dom is delighted when he learns he is going to Hawaii with Isaac, but he crushed when he discovers there's a catch. Fletch struggles to come to terms with his fate.
A familiar face returns to Holby as a patient. Jasmine feels the wrath of Serena's grief. Jac is determined to keep her and Matteo's relationship on the low.
Jac acknowledges her true feelings for Matteo. Bernie provides a shoulder for Serena to lean on. Raf is determined to keep his distance from Kim when she is readmitted to the hospital.
Isaac's paranoia over Dom leads him into danger. Mo and Mr T evaluate their childcare arrangements. Morven grows worried by Serena's abrasiveness towards Jasmine.
Raf is delighted by Kim's revelation, but his happiness is quickly dashed. Serena continues to intimidate Jasmine. Matteo hopes that he can learn more of Jac's personal life.
Jasmine's determination to prove herself to Jac and Serena comes at a cost. Essie worries for Kim's son. Ollie tries to convince himself he is no longer angry at Jac.
Dom attempts to cover for Isaac after accusations are made against him. Fletch makes a discovery about the man Morven has been messaging. Zosia's personal and professional lives collide.
Essie is put in an uncomfortable position. Zosia is determined to keep her secret from Ollie, unaware that Isaac knows. Serena helps Fletch cope with his adolescent daughter.
Dom is the victim of Isaac's violent outburst. Serena struggles with her grief when treating a patient who reminds her of her dead daughter. Ollie makes a decision about his and Zosia's future.
Dom is supported by the staff at Holby when Isaac's abusive streak is exposed. Fletch's positive attitude is dampened by an agency nurse. Matteo takes it upon himself to unite Jac and Jasmine.
Matteo is forced to face up to his past. Dom struggles to remain professional on his first day back at work. Bernie's son returns, providing Morven with a distraction.
Jac juggles the big reveal of her new project with the return of a familiar face as a patient. Ollie plans a big surprise for Zosia. A familiar agency nurse arrives at the hospital.
Lofty must confront his past. Mo unsuccessfully attempts to take on Jac's role. Jasmine worries after failing to recall the phone calls she made whilst she was drunk.
Mo and Mr T are left fearing for baby Hector's health. Nina is determined to keep a professional relationship with Matteo on her first day. Raf makes a startling discovery as Essie helps Dom form a team for the Holby half marathon.
Sacha is forced to take action against Dom's erratic behaviour. Fran is encouraged by Jasmine to seek support from Jac on her first day back. A new face sets foot on Darwin ward.
Mo questions how long she can continue working at Holby City. A family member of Ric's is admitted. Fran steps in as Jasmine and Jac's relationship continues to thaw.
Jasmine delves into Jac's past, unaware of the demons she is freeing for both Jac and Fran. Damon's first day is one he won't forget for a long time. Dom is left at odds with Lofty.
The staff at Holby City support each other in the aftermath of Jasmine's death. Jac is determined to not allow her feelings to weaken her superiority. Donna clashes with Fletch on her first day back.
Morven begins investigating Jasmine's death herself. Sacha treats a patient close to home. Damon suggests to Matteo that there is still hope for him and Nina.
Essie's private responsibilities clash with her professional ones. Bernie tasks Donna with keeping an eye on Morven. Jac is determined to get her job back on track.
Ollie grows weary of Guy's intentions. Sasha is given a prompt over his belief in God. Nina questions Matteo's feelings towards her following their return from an unromantic weekend away.
Zosia is given a rare opportunity to further her career, but it comes at a dear cost. Ollie struggles with the prospect of his ex-wife's death potentially being preventable. Lofty fears that Dom's not getting the message.
Events take a tragic turn at the Holby half-marathon. Lofty is forced to confront his true feelings towards Dom. Fletch enlists Jac's help when there is a shortage of theatre beds. Guy puts Zosia to the test.
Hanssen must confront a face from the past. Fredrik is determined to impress Sacha, Dom and Lofty. Guy's behaviour is a cause for concern for Zosia. Donna makes it her mission to teach Fletch a lesson.
Ollie is stunned by the permanent return of a face from his past. Nina inadvertently increases the rivalry between Dom and Fredrik. Lofty struggles with his transition to a new ward.
Ric desperately defends his innocence at the coroner's court as Donna considers lying to save him. Dom searches for a new research project. Jac is dismayed by the return of a useless agency nurse.
Hanssen and his team prepare for Holby's biggest challenge yet. Oliver has to juggle a demanding patient and his fixation over finding a lost possession.
Fredrik seeks guidance from Nina in order to impress Hanssen. Donna's interview date for Ric's case arrives. Damon is faced with an unusual complication.
Jac braces herself for one of the biggest moments of her life. John Gaskell arrives at the hospital, putting the wheels of change into motion. Raf is reminded why he fell in love with medicine in the first place.