16-year-old Keith Foster suddenly starts bleeding while joy-riding with his cheeky girlfriend Pam behind the wheel of his dad's Porsche. Mr. Foster fears ex-junkie Pam got his good boy on drugs. Keith tests clean yet shows a confusing set of symptoms, including blood clots, hemophilia, liver failure, vomiting and hallucinations. After various negative tests and Chase's success at preventing him going blind, only hyper-rare hepatitis E (possibly caught on foreign travels) or lupus (immunity turning against the patient himself) seem likely. House, grumpier than usual, remains increasingly distracted due to a wager with Cuddy: one month off clinic duty for one week off Vicodin (to prove he's no addict). Through his haze of pain, House comes upon a possible clue to Keith's life-threatening ailment- a death in the family no one felt worthy of mention.
KGF Vissers/revised by statmanjeff
Did You Know?
When Wilson says to House "I wanted to make sure you don't start firing shots from the clock tower", he's referring to the Texas Clock Tower shooter, Charles Whitman, who shot people from a clock tower at the University of Texas in 1966. See more
Opiate is a term used to describe the naturally occurring narcotics in opium, which are mainly codeine and morphine, whereas opioid is a term used for the semi-synthetic analgesics like hydrocodone (Vicodin, Lortab and Norco), oxycodone (Percocet and OxyContin) and Hydromorphone (Dilaudid), as well as the fully synthetic narcotic analgesics like methadone and fentanyl. When House exhibits the effects of opioid withdrawal, Dr. Cuddy states it is because House is addicted to the Vicodin; however, just because someone is experiencing withdrawal after stopping an opiate or opioid does not mean that they are addicted. It just means that their body, mainly the brain and nervous system, had become tolerant to the drug. Only some people using opiates and opioids become addicted to them (meaning they take the drug for the high). Everyone else taking opiates or opioids for more then a couple weeks just becomes tolerant to the drug because of its similarity to chemicals secreted in the brain, mainly endorphins and dopamine (our bodies' natural painkiller and "feel good hormone"). In fact, endorphins are very similar to morphine, both chemically and in its effects on the nervous system; so, since these drugs are a lot like those chemical neurotransmitters secreted in the brain, the brain stops making them. Any sudden halt to taking opiates or opioids throws the brain into a chemical imbalance, which is what withdrawals are. Once our brains are able to catch up and start producing normal levels of endorphins and dopamine, the withdrawal subsides. To sum it up, going into withdrawal after the cessation of opiates or opioids does not necessarily mean one is addicted to them. See more
[Dr. House, to delay a surgery, has violently sneezed and coughed all over the sterile Dr. Hourani
There's no way we can do the surgery now.
References The Deadly Tower
You Don't Have To Worry
Written by Wayne Jones
and Windy Wagner
Performed by Windy Wagner See more