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Title: The Incredible Hank (23 Nov 2003)
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| Episode cast overview: | |||
| Mike Judge | ... | Hank Hill / Boomhauer (voice) | |
| Kathy Najimy | ... | Peggy Hill (voice) | |
| Pamela Adlon | ... | Bobby Hill (voice) (as Pamela S. Adlon) | |
| Brittany Murphy | ... | Luanne Platter (voice) | |
 |
Johnny Hardwick | ... | Dale Gribble (voice) |
| Stephen Root | ... | Bill Dauterive (voice) | |
| Toby Huss | ... | Kahn Souphanousinphone Sr. (voice) | |
| Ashley Gardner | ... | Nancy Hicks Gribble (voice) | |
| Nicky Katt | ... | Dr. Brown / Old Man (voice) | |
| Breckin Meyer | ... | Joseph Gribble (voice) | |
| Lauren Tom | ... | Minh Souphanousinphone / Kahn 'Connie' Souphanousinphone Jr. (voice) | |
| Danny Trejo | ... | Victor Velasquez (voice) | |
Peggy suspects that Hank suffers from Irritable Male Syndrome and begins spiking his coffee with testosterone, turning Hank from low-energy everyman to muscled go-getter.
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Hank, worried Bobby may be developing more slowly than he should be brings him to a doctor hoping Bobby will be prescribed testosterone to "jump start" his puberty. The doctor determines Bobby is developing normally, but Hank is suffering Irritable Male Syndrome and prescribes testosterone for Hank, which he refuses to take. Peggy believing the diagnosis is correct begins slipping Hank the medication and hilarity ensues.