Archer is working at a burger shop, but can't remember any of the events that led to him working there. Fortunately, Malory takes the Isis crew to a luxury spa and Lana helps Archer cure his amnesia.
With Barry stuck in space, Archer's former fiancée Katya, who is now living as a cyborg herself, seeks Archer's help in getting Barry returned to earth. But as manipulative as Archer is, he has other plans in mind.
While accompanied by Cyril and Ray on a mission in Turkmenistan, Archer comes in contact with a venomous snake with hallucinogenic repercussions. Meanwhile back at ISIS tensions come to a head between Lana and Malory.
The Isis crew heads to the Mexican border to save a coyote, but Archer and Lana soon find themselves being smuggled over the border with an immigrant family.
Archer and Lana are on a mission as a couple staying in the honeymoon suite. Their colleagues are spying on them. The North Koreans are in NYC to buy uranium.
The Isis crew heads to the Vatican to stop an assassination attempt on the Pope. Archer attempts to use Woodhouse as a decoy, while Archer and Pam pose as a priest and a nun.
The Isis crew heads deep into the Bermuda Triangle to save an underwater sea laboratory from its deranged leader, thanks to the help of Cheryl's dim-witted brother and his equally dim-witted fiancée, who drive Cheryl crazier than usual.
Once on board the underwater laboratory, the Isis crew find they have very little time to rescue the lab from its deranged captain. But of course, the Isis crew's conflicts and Archer's recklessly impulsive tendencies don't exactly help things.