Neve Campbell stated on June 6, 2022, that she would not be reprising her role of Sidney Prescott, after starring in the five previous entries, due a salary dispute with Paramount. Campbell's statement read, "As a woman I have had to work extremely hard in my career to establish my value, especially when it comes to Scream. I felt the offer that was presented to me did not equate to the value I have brought to the franchise. It's been a very difficult decision to move on. To all my Scream fans, I love you. You've always been so incredibly supportive to me. I'm forever grateful to you and to what this franchise has given me over the past 25 years." After Campbell announced that she wouldn't be reprising her role as Sidney, her former Scream co-star
Matthew Lillard offered his support for her decision. "Did Tom Cruise take less money for Maverick 5 [sic]?" he asked, insisting that a woman should not be expected to take a smaller paycheck. He noted that Scream V was a "smash hit," and that Campbell should be paid accordingly.