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(At around one hour and twenty-two minutes) This movie's action takes place in 1755. During the third act, Captain Hector Barbossa (Geoffrey Rush) said that it has been five years since Blackbeard shrunk The Black Pearl in the bottle. The producers have said that Pirates of the Caribbean: On Stranger Tides (2011) took place in 1750. This also means that Henry is twenty-one years of age, given that he was twelve during the prologue, two years after the post-credits scene of Pirates of the Caribbean: At World's End (2007).
The father of Captain Jack Sparrow was played by a Rolling Stone (Keith Richards), and in this movie, the uncle of Captain Jack Sparrow was played by a Beatle (Sir Paul McCartney).
This movie was being produced as Johnny Depp was going through a bitter divorce. He was chronically late to the set, to the point where it ate into the schedule as the set often came to a halt for several hours at a time. It got to the point where a production assistant was hired just to wait outside Depp's house and announce that he was awake when they saw the lights inside come on.
Although this movie was initially claimed to be the last one in the franchise, a sixth installment was announced after its release.
Because Will Turner (Orlando Bloom) is the Captain of the Flying Dutchman, he can only set foot on land once every ten years. This movie was released ten years after the third movie, which was the last one with Will.
(At around six minutes) Henry (Lewis McGowan) recognizes a ship as Bonnet's ship called "Royal James". Stede Bonnet was a real-life pirate who worked closely with Edward Teach, a.k.a. Blackbeard. Bonnet was active from December 1717 to December 1718 before he was hanged in Charles Town for piracy.