Dean takes on his first assignment since his promotion, piloting the Clipper Majestic on its inaugural New York to London flight. Bridget is supposed to be his lead stewardess, until she's a no-show for the flight. Grounded purser Maggie is called in to fill in for her. On the same fateful flight, Kate adds another dimension to her work as she takes on her first assignment from U.S. intelligence. Her stress is compounded when she discovers that newly minted stewardess, Laura, her sister, is also working the same flight.
On a trip to Paris, Kate and Laura have a surprise passenger - their mom - who has come to settle some unfinished business with Laura; Maggie faces the unwanted attentions of an aggressive passenger, and Dean and Colette share a momentary flirtation as he tries to track down some leads on Bridget.
When the crew gets a flight taking journalists to Berlin to cover an important speech by President Kennedy, Maggie, who campaigned for him, is determined to meet JFK no matter what. Meanwhile, when her contact's safety is compromised, Kate tries to help the young woman escape East Germany; and painful memories of World War II force Colette to face her tragic past.
After a last minute change sends the crew on a flight to Rangoon, a routine courier mission for Kate turns harrowing as she struggles to make a drop by the deadline. Meanwhile, Maggie takes naive Laura under her wing and shows her the wilder side of the city; and news of a space mission leads Ted to reflect on his own past and what his powerful family connections have cost him.
The Pan Am crew rolls the dice in more ways than one in glamorous Monte Carlo: Kate and Maggie square off for the attentions of a handsome passenger, but things get more complicated when Kate learns the sexy stranger is involved in her next covert mission; and Dean gambles with his career when an attractive, wealthy woman on the flight tempts him -- and he later discovers who her flying companion is.
Maggie is perilously close to losing her job for insubordination, but still manages to maneuver her way onto the flight down to Rio de Janeiro. She reflects back on the rocky path she took to land her dream job, but it's her decision to do whatever it takes to keep it that surprises even her. Meanwhile, Kate has earned her stripes as a courier, but when she is given a difficult mission involving Niko, a Yugoslavian diplomat, she's unsure how to manage the task, as she tries to juggle their deepening personal relationship with her assignment. Finally, Ginny and Dean ...
Sparks fly between Laura and a sailor on a special - and unusually wild -- Pan Am flight bringing servicemen home, leading Laura to realize what she's really looking for in a man, as well as opening her eyes to the malicious racial climate in the country. Meanwhile Kate's complicated mission to turn Niko to work for the U.S. government culminates in dramatic fashion, threatening their personal relationship.
As the crew flies to Caracas, a dashing, wealthy passenger, Miguel, charms the stewardesses with invitations to his yacht. Meanwhile another passenger, Henry Belson, suffers a heart attack, but there is no doctor on board to help out. The only hope of saving his life is to land in nearby Haiti to seek medical help. However, Haiti is a hotbed of local political unrest, reeling from tropical storms which downed trees and affected power - including the lights on the damaged runway. Colette and Ted team up to to make the dangerous trek for medical help.
Once in London, Ted enlists Laura's help to try to make an old flame - Amanda Mason - jealous, but things don't go the way he expects. Meanwhile, Kate attempts to regain her freedom from her courier duties by agreeing to one last mission for her British contact, but the dangerous assignment not only puts her life in jeopardy but Anderson's as well; Maggie butts heads with a hawkish congressman who disagrees with her political views, but things really heat up when she tries to change his mind about his beliefs and ends up sparking an attraction with him; and back at ...