Tom Kane cements his mayoral legacy with a lavish ceremony celebrating the groundbreaking of the new modernized O'Hare terminals. Now Kane looks to the future, setting his sights on reviving a subsidized housing project. While his political future seems bright, Kane continues to battle for control over his disease.
Kane uses a tragedy in his personal life to further his political agenda and ultimately win control over the housing authority. Kane tries to remedy his fractured inner circle by poaching his nemesis' senior aide, Mona Fredricks, and hiring ambitious newcomer Ian Todd - but will they be enough to fill the void?
Kane grows increasingly infatuated with his new senior aide, Mona, allowing himself to get swept up in her passion for the subsidized housing project. Ben Zajac and his wife, Maggie, run the risk of alienating themselves from Kane when they take the reins of Zajac's gubernatorial campaign.
Kane makes a professional turn to a new way of doing things when he extricates the housing project from the corruption that plagues his entire city. Kane's young aide, Ian, has a threatening secret that he manages to hide from Kane. Kane tries to reconnect with wife, Meredith, and daughter, Emma, but his attempts at a harmonious family are disastrous.
Kane orders a corruption sweep and arrests several members of his own political machine. Kitty O'Neil crushes Zajac's campaign just as he is on an upswing. Kane spirals out of control when his mental symptoms reach a boiling point and he can no longer distinguish between his hallucinations and reality.
Kane's moves with the housing project escalate from a state of unrest to rioting and looting. As Chicago burns, Kane secretly seeks treatment at an alternative clinic where his past haunts him. In Kane's absence, his wife, Meredith, steps into the mayoral role.
Kane's alternative treatment seems to have worked and he is back in control of his city. Meredith moves full force into her role as Chicago's First Lady but she soon discovers Kane's obsession with his aide, Mona. Kane must remedy his public perception even if it means making an old friend collateral damage.
Chicago is bankrupt and a team of receivers pour in to take control of the city. But losing his mayoral power isn't the biggest danger to Kane as various enemies including Sentinel editor, Sam Miller, threaten to expose his illness and corruption. Does Kane have a plan in his back pocket or will he go down with his city?
As Kane's mental faculties deteriorate to a new low, Sentinel editor, Sam Miller, is about to break a story that will destroy him. But unbeknownst to Kane, Kitty is the true threat as she decides where her loyalties lie. As the odds stack up against Kane, he will be forced to reveal the unthinkable to stay on top.