- Bernadette and Penny travel to San Diego for a pharmaceutical sales convention. Back home, Amy and the guys experiment on the Wolowitz children when Sheldon finds a book on it.
- Bernadette and Penny are attending a pharmaceutical conference in San Diego to promote the new drug. Penny is taking the job seriously in wanting to put the company and the drug in a good light. Penny may do too good a job as Danny, the rep for a competing drug company and a person that Bernadette seems to detest, woos Penny to join their company. Penny even talking to Danny may place both her and Bernadette's professional and personal relationships on the line. Bernadette being gone leaves Howard to look after the two kids on his own. Wanting some company, he invites all his friends over for a day of board games. While Leonard and Raj readily accept, Sheldon and Amy, who weren't going to attend because of Sheldon's want not to hang out with the kids, are last minute attendees. The reason for them attending ends up taking over the day, that reason, which may have seemed spontaneous, actually being manipulated by someone for his/hew own ulterior motive, that manipulation which may work just a little too well.—Huggo
- At Zangen, Penny is conducting a sales meeting discussing their product Inflaminex drug and pushing their slogan "It's a brand new day," which Penny came up with. Bernadette comes in wondering why they are still there. Karen exclaims that they are happy to be there because "It's a brand new day." As it is since it was now 12:15 A.M. Bernadette tells everyone to go home, but they don't move until Penny agrees.
Bernie is coming down the stairs with her luggage on the way to their conference to launch Infaminex. Howard is in charge of the baby sitting. Bernadette reminds him that it's "parenting". She gives him a quick quiz: Where are the kids? "Upstairs" replies Howard. "They're at daycare!" That wasn't really true because his wife was messing with him.
As Penny is getting to leave, Leonard is worried that because of all of her luggage, she might be leaving him. The Coopers burst in because Sheldon has a bet with Amy. Since Penny is heading to San Diego, she needs to look for people walking around in superhero costumes. He contends that since ComicCon is in San Diego and people wear their costumes to ComicCon, some in San Diego wear them all year round.
At the comic book store, Leonard is wondering what to do over the weekend since he is alone. Sheldon invented a new version of chess while Howard invites them over to play board games AND help watch the kids. Sheldon doesn't want to spend time around loud sticky children.
At the conference, Penny is pushing their drug and ending her pitch with "It's a brand new day!" Bernadette thinks she is doing great. Penny adds, "Mediocre actress, great drug pusher. Who knew?" Another guy named Danny Jacobs approaches who Bernadette hates since he works for their competitor. Their inflammation drug is also coming out at the same time.
At home, Howard has the kids down while Leonard and Raj set up a card game. Sheldon and Amy come in. Sheldon has decided to spend some time with the Wolowitz kids since he found a book on 50 experiments one could perform on children. Howard doesn't like the idea so Sheldon pushes it as playing with Halley and Michael.
Later Amy is looking through the book and finds that the experiments are as simple as letting the baby discover his reflection in a mirror. Amy can find the projects adorable, but when Sheldon proposes it, it just sounds creepy. Raj finds an experiment where you can check the kid's hand dominance or whether they are right or left handed. Howard agrees that they can try it when his kids wake up.
When Bernadette comes to take a phone call, Danny then approaches Penny. He knows that Bernadette doesn't like him. Then he tells Penny that she is doing a great job launching their product and that they are always looking for great sales people and that they could make Penny happy.
Bernadette receives a call from Howard who wants to know where the barbecue tongs are. She asks if he was going to grill, but they were playing a game with the kids and he hangs up. The guys are dangling objects over Michael and Halley. Sheldon wants to up the experiment so that they will have something to publish.
Danny is still talking to Penny when Bernadette returns. She tells him to leave and wants to know what he wants. Karen blabs that Penny was offered a job.
While Sheldon sets up the experiment on the subjects, Leonard feels like something was very familiar about what was going on. He had been experimented on all throughout his childhood by his mother. Raj and Sheldon are trying to get reactions from the kids and Halley calls Raj "Unka Koo". Sheldon is very excited about working with the kids and wants to do a feeding experiment when it comes time for the kid's dinner. Raj is surprised that Sheldon is so happy around babies. He finds it interesting that they found the book the same day that Sheldon and Amy were going to hang out with Howard's children. Leonard is having flashbacks of being experimented on when he was a kid.
Back in their hotel room, Bernadette is peeved that Penny took Danny's business card. Penny figures she should at least take his card, while she was flattered by his comments. Bernadette tells Penny that she gave her the job since no one else wanted to head the sales team.
Raj comes into the living room eating a pear. He sits down with Amy while Howard and Sheldon are giving the kids a bath. Raj asks if she thinks she can trick Sheldon into liking kids. She did get him to sleep with her and marry her. Sheldon comes down talking about all the experiments they did and he gets excited that maybe they could take them to the park the next day. She glances back at Raj to show him that she knows what she is doing.
Leonard is still there talking to his mother who admits to performing thousands of small experiments on him as he was growing up and that the experiments are still going on. She also admits that watching him grow up, develop and tracking his progress were some of her fondest memories of him.
Penny is having a drink with Danny as he proposes to offer her a new Mercedes if she joins them. He's willing to make an offer, while Penny wants him to write it on a napkin and slide it over to her like they do in the movies. After he writes it down, Bernadette storms in, grabs the napkin and says that Penny is amazing. She is the best salesperson and the hardest worker Bernie has ever seen. Penny says that she is happy where she is, but still wants to see the offer on the napkin. Bernie asks her "What napkin?"
Finally, Sheldon and Amy are crawling into bed as Sheldon says that he had a good day and that he was thinking about their future children. That surprises Amy though there is a slight smile on her face. Sheldon still seems to want fifteen kids, three sets of quintuplets or five sets of triplets - as long as it's divisible by three. Amy admits that that is a lot of children, but not for a frog, adds Sheldon. Amy apologizes for not being a frog. Sheldon gives her a kiss and tells her that she is good enough for him.
Title reference: Penny being valued as a saleswoman at the pharmaceutical conference.
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