The Irish family appearing in this episode (Welcome to the Alternate Economy) have the surname Milligan. In Season 2 of Fargo--set in Minnesota, North Dakota, and South Dakota in 1979-- actor Bookeem Woodbine portrayed a character named Mike Milligan, a black hitman employed by the Kansas City mob.
The opening title card doesn't appear on screen until 22 minutes into the episode.
Filming for Season 4 began on location in Chicago, Illinois. [October 15, 2019]
The bus featured in this episode is of similar design and paint scheme as the bus Rosa Parks made famous at the beginning of the civil rights era.
When the nurse gets off the bus and goes into her apartment building it shows the 3rd floor. At the end of the show she is shown in the 2nd floor of the building