In the spirit of No Country for Old Men, Man on Fire, and Witness, November Road is a story of second chances and redemption. It's November 22, 1963, JFK has just been assassinated, and all Frank Guidry was supposed to do was get rid of the car - the same car, he realizes, that he had personally delivered to Dealey Plaza a week before. This connects him to the president's murder and, when other loose ends begin dying all around him, Frank knows he's next. Hunted by a ruthless hitman hired by his ex-boss, Frank heads across the desert where he meets Charlotte Roy, who is running away from her smalltown life and abusive alcoholic husband with two young daughters and an epileptic dog in tow. Guidry sees this instant family scenario as the perfect cover and while he might get her killed, Charlotte sees him as her best chance at a new life, if they can escape before his past catches up to him.