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- When Dr. Mike and Sully's daughter Katie is kidnapped, they and a group of townsfolk travel to Mexico to rescue her.
- A ghostly gas station attendant kills off a group of campers who realize he is the reason for the legend of campers routinely coming to the woods to commit suicide.
- A Salute to Dr. Quinn, Medicine Woman transports viewers behind-the-scenes of the hit series.
- 1993–19981h 30mTV-G7.7 (581)TV EpisodeMichaela Quinn, a female doctor in post-Civil War Boston, Massachusetts, finds more than she bargained for when she answers an ad for a doctor in a small town in the Colorado territory.
- A wandering cowboy abandons his baby boy and leaves him in Dr. Mike's care.
- The town's Christmas spirit is in question when a family who are Jewish immigrants moves to town.
- 1993–199847mTV-G8.3 (116)TV EpisodeGeneral Wooden is injured by dog soldiers and dies. Daniel talks with Sgt. McKay and the non-violent Indians are let free. Hank takes over as sheriff temporarily. Daniel runs for sheriff and wins. Sully and Cloud Dancing work for peace.
- Dr. Mike's elation at Colleen's acceptance to medical school quickly turns to disappointment when Colleen chooses to marry Andrew before starting school. A bitter family argument erupts when Dr. Mike tells Colleen that she is less than overjoyed at her announcement and feels that the couple is rushing into marriage and should wait until Colleen completes medical school. Meanwhile, Jake's sale of his half of the Golden Nugget to Preston angers Hank; Robert E and Grace have wonderful news to share; the stock market crash hits Preston and the townsfolk hard, and Dorothy and Cloud Dancing reach a new level in their relationship.
- Dr. Mike and Sully return from their honeymoon and begin unpacking at their new homestead. A Boston banker comes to town and stirs up controversy among the townspeople as the inevitability of progress ensues.
- Dr. Mike worries about how to tell Robert E. and Grace that their adopted son Anthony may not survive his mysterious illness. Meanwhile Sully struggles with convincing the renegade braves to return to the reservation and learning about Dr. Mike's recent miscarriage.
- Dr. Mike desperately attempts to find out why patients are dying mysteriously after having been treated in her clinic. As Dr. Mike searches for the answer to why a deadly and mysterious infection haunts her clinic, the townspeople begin to fear coming in for treatment. Unable to find out what is causing the deaths, Dr. Mike then makes a fateful decision that could mean destroying everything she has worked for through the years. Meanwhile, the attraction between Colleen and Andrew grows while she is home from college for a visit.
- 1993–199846mTV-G7.9 (121)TV EpisodeDr. Mike's mother and oldest sister visit for thanksgiving just as an outbreak of diphtheria hits Colorado Springs.
- 1993–199847mTV-G8.4 (116)TV EpisodeDr. Mike struggles to control the diphtheria outbreak and disagrees with Andrew on whether to use a new treatment.
- Colleen considers leaving college when the famous singer, Gilda St. Clair, offers her a job traveling the world with her.
- Dr. Mike, Matthew, Brian and Daniel find a seriously wounded Sully and move him to a cave near the homestead so they can nurse him back to health while hiding him. Dr. Mike starts working to clear Sully's name.
- A woman who has been living with Native Americans for over ten years is found and brought to Colorado Springs. Tensions rise between Sully and Mike when the girl becomes unusually attached to Sully.
- A teenage Belle Star robs the saloon with the Younger brothers and is shot. Dr. Mike takes her home in an effort to show her a real home life, attempting to turn her from her life of crime.
- When the town's water supply is tainted with mercury by a wealthy mining baron, many people become sick and Dr. Mike threatens the miner to clean it up or have his land taken away.
- When he gets the papers for his divorce from Myra, Horace attempts suicide and almost succeeds. His friends do what they can to help him, but it turns out that depression isn't always cured that easily.
- Dorothy thinks she's pregnant, but Dr. Mike's exam reveals there are other problems going on. The upcoming Sweetheart Dance causes trouble between Sully and Dr. Mike. Colleen and Becky squabble over a boy, while Dr. Mike suspects something fishy going on between Sully and Dorothy.
- 1993–199843mTV-G7.4 (142)TV EpisodeSully's best friend Daniel arrives for a visit, but the relationship becomes strained when Daniel offers Sully money at a time when Sully desperately needs it to save the homestead.
- 1993–199843mTV-G7.5 (134)TV EpisodeAfter Preston calls the loan due on the homestead while Sully is gone, Dr. Mike reluctantly accepts Daniel's offer to pay it off, further straining relationships. Things are also complicated because Daniel has fallen in love with Dr. Mike.
- Dr. Mike grapples with her fear for Brian's safety when the youngster befriends a seemingly harmless but eccentric fellow who thinks he's a bird and covers himself with feathers in an attempt to fly. Martin Von Hoffman, the birdman, not only tries to fly, he also sleeps in a nest and literally pecks at his food when Dr. Mike invites him home for dinner. To her alarm, Martin turns out to be an escapee from a New York insane asylum. She is torn between returning him to the asylum or allowing him to carry on his self-deception in peace.
- Brian's dog Pup gets bitten by a rabid raccoon. Then Matthew's fiancée gives the dog water. She also gets bitten.
- A troop of buffalo soldiers comes to town and with them the idea that the government was using them instead of white soldiers, because it was felt they were more expendable.
- Loren's sister, Miss Olive, has died and bequeathed her cattle to Matthew who, along with Dr. Mike, Sully, Colleen, Brian, Loren, Robert E, and Grace, attempts to bring the cattle back to a ranch near Colorado Springs.
- The Cattle Drive continues with various difficulties to overcome including conflicts between Matthew and Sully, cattle rustlers, hungry Indians, and a prairie fire. Dr. Mike delivers a calf, and Sully helps her clean up afterwards.
- A young orphan boy is taken in by Grace and Robert E. begins to show symptoms of an unknown health problem.
- Dr. Mike reluctantly takes on the role of temporary judge when Horace sues Hank for accidentally breaking his nose and sets off a flurry of suits and countersuits among the town's citizens. Matthew, who has been studying the law, tips off Horace that he's legally entitled to have Hank pay his medical bills. Soon Dr. Mike finds herself in the middle of that case, as well as a property dispute between Dorothy and Grace and a claim by Loren that he was crippled and nearly drowned because of negligence at Preston's hotel.
- When Colleen, who is working on a college paper, asks Dr. Mike to recall her most memorable case, Dr. Mike looks back on the five turbulent years she's lived and loved in Colorado Springs. As they sit with Andrew, who is mysteriously ill at the clinic, Dr. Mike reminisces about her tumultuous career -- its successes and its failures -- and realizes how many divergent cases she has seen and treated. When Andrew's condition takes a turn for the worse, Dr. Mike warns Colleen about the fine line between emotional involvement and professional detachment, an issue with which she has long struggled in the frontier town that's now her home.
- 1993–199843mTV-G8.0 (111)TV EpisodeColleen and Brian's biological father Ethan returns to town with a new wife, intending to take the children away from Dr. Quinn. The children don't want to go but a court hearing seems to work against Sully and Dr. Mike, who they consider their parents.
- 1993–199843mTV-G8.3 (119)TV EpisodeColleen and Brian run away to keep their father from taking them away from Dr. Mike and Sully. After they are found it's discovered Colleen has developed pneumonia. Dr. Mike realizes she has to let them go to save them.
- When the silver miners strike, Matthew is eager to take a scab job mining for the quick cash. But, with disastrous results.
- 1993–199847mTV-G8.1 (110)TV EpisodeWhen a politician's son is kidnapped by a fierce, legendary mountain man, Sully must lead a rescue party to the remote site where a highly unusual ransom is to be paid.
- 1993–199848mTV-G8.4 (110)TV EpisodeWhen Ezra Leonard offers a $1000 reward to the capture-dead or alive- of the mountain man who kidnapped his son, Sully's rescue party turns into an unruly mob. Dr. Mike must accept help from Dr. Cassidy to save her pregnancy.
- News from his former mentor's upcoming visit has the Reverend Johnson rushing to ensure he makes a good impression. He quickly attempts to raise enough money to fix up his dilapidated church.
- Dorothy gets her book about the town published, but the townsfolk read her depiction of them differently than she intended.
- Miss Olive arrives back in town and believes that she should be the one looking after Matthew, Colleen and Brian. She brings with her a sick cowboy who had contracted influenza but everyone is unaware of the exact nature of his illness. Michaela attempts to try her hand at cooking but is unsuccessful. After the cowboy dies and his child becomes ill with the same thing Dr. Mike discovers that it is influenza. People in the town were dying and Dr. Mike wanted to quarantine people who are sick in Charlotte's boarding house. Brian comes down with the influenza and Colleen begins to think that Dr. Mike only wants to treat people instead of being their guardian and starts to resent her. Dr. Mike is running out of medicine and Sully suggested Cheyenne brewed tea but she does not want to administer a drug she is not familiar with. Dr. Mike uses the last bit of medicine for Jake, Brian and Horace. Brian's fever finally breaks and Dr. Mike is relieved but she herself now has influenza. Sully had Matthew go for Cloud Dancing, Medicine Man. Will they get back in time?
- When a stranger is convicted of raping a young girl and murdering an old man, he is sentenced to death. Some people are conflicted about whether or not it is right to take "an eye for an eye".
- On a visit to Colorado Springs, Dr. Mike's revered Uncle Theodore shocks her and Sully by criticizing their parenting skills with regard to Brian and offering to take Brian back with him to Boston. Brian considers leaving his family when Theodore, a concert pianist, recognizes the boy's musical talent and tempts him with visions of becoming a concert pianist in Boston. Actually, Theodore dislikes what he considers to be the "liberal attitudes" of Sully and Dr. Mike that he feels put Brian in danger. When Brian is injured while on the trail with Sully, Theodore can no longer hide his feelings and Dr. Mike realizes that her uncle is attempting to replace his own lost son with Brian.
- Michaela worries when Charlotte's husband, Ethan Cooper, comes back to the family he abandoned, convincing almost everyone of his newfound ways.
- When Loren sets out to prove he's not too old, and Brian wants to prove he's old enough, the two embark on individual journeys that intersect. Loren shocks everyone when he announces that he's going to travel to Bolivia, to prove to himself and to everyone else that he's not too old for the treacherous adventure. While he's away, Brian takes off on his own little adventure -- to camp out alone at night and brave the elements. But an unexpected travel companion -- a grizzly bear -- unites the two "men" in a shared adventure neither anticipated.
- Isabelle Maynard, an attractive painter, arrives in town attracting the eligible bachelors particularly Preston. But after the citizens learn Isabelle has leprosy they are determined to drive her out of town over Dr. Mike's objections.
- 1993–199847mTV-G7.6 (117)TV EpisodeDr. Mike and her family receive an unexpected gift from Boston, a small poodle unsuited to life on the frontier. Brian has his first crush on Sara, Preston is embarrassed by a painful kidney stone, and the Reverend plans a living nativity.
- 1993–19981hTV-G7.8 (141)TV EpisodeThe town of Colorado Springs is preparing for an event of a lifetime, the marriage of Sully and Dr. Mike. Unexpected guests include Dr. Mike's mother Elizabeth Quinn and two of her sisters Rebecca and Marjorie. They have brought with them enough Boston finery to pull off a splendid society wedding. Meanwhile General Custer has put out a bounty on Cloud Dancing which could interfere with the wedding.
- 1993–19981hTV-G8.4 (147)TV EpisodeBolstered by the long-awaited arrival of the railroad, the citizens of Colorado Springs busily prepare for the biggest social event in the town's history, the wedding of Dr. Mike and Sully. The first train carries some surprise visitors, Dr. Mike's mother, Elizabeth, and sisters Marjorie and Rebecca, who have unexpectedly traveled all the way from Boston for the occasion. However, their elaborate wedding plans threaten to ride roughshod over the townsfolk's more homespun arrangements. Sully, meanwhile, is crestfallen to learn that Gen. Custer has placed a bounty on the head of his close friend Cloud Dancing, who he had planned to have as his Best Man.
- Mike is forced to rethink her relationship with Sully after a visit from his ex wife's ghost.
- Brian rescues a man from a trap who has horrific burns to his face from a train crash. Michaela decides to perform reconstructive surgery to repair his face.
- Elderly Abner Foley comes to town looking for alternative treatment and a very friendly dog adopts Jake Slicker. The rest of the town looks forward to the costume party but first Brian must face a very big fear.
- As Jake and Teresa look forward to their wedding day, Dr. Mike and Sully struggle to free Cloud Dancing, who was captured and put in prison for leaving the reservation. Dorothy is so disturbed at the thought of Cloud Dancing in jail that she contemplates helping him escape and fleeing with him into the wilderness. Meanwhile, Teresa introduces Jake to her visiting aunt, Dona Verano, and her cousin, Carlos, a priest. The visit turns sour when the older woman takes an immediate dislike to Jake and tries to prevent the marriage.