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1-24 of 24
- Guilt causes different actions in everyone, the interns are allowed to attend an M&M meeting, and Derek and Addison finalize things.
- Everyone reminisces about the past. Meanwhile, Izzie is emotionally devastated, with the others trying to help her, Adele gives Richard an ultimatum, and George and Derek are put in quarantine when an outbreak of the plague is suspected.
- Izzie copes with her grief by baking furiously, and George has to deal with an obstinate patient. Meanwhile, Meredith must choose between Derek and Finn, Addison drowns her sorrows in alcohol, and Cristina meets Burke's difficult mother.
- Izzie returns to the hospital, but finds it difficult to go inside, and George is tired of Callie's presence at home. Meanwhile, Addison cannot seem to get rid of Mark, and Cristina tries to cope with caring for Burke.
- Izzie returns to the hospital under probation, and George tries to make amends with Callie. Meanwhile, Cristina's deletion of Bailey's name on Burke's OR board makes her assume he is against her, and Derek's irritating sister Nancy visits.
- Meredith becomes a patient, and Derek and Addison are equally angry at Richard for allowing Mark to join the staff. Meanwhile, Izzie receives a visit from Denny's father, and Burke is plagued by doubt over his ability to return to surgery.
- Derek, George, Alex, Burke, Richard, Joe and Walter go on a camping trip. Meanwhile, Meredith assists Mark with gender reassignment surgery, Izzie avoids discussing her grief, Addison works with Callie, and Cristina feels Bailey's wrath.
- George deals with his grief, Cristina and Burke continue to ignore each other, Addison avoids Alex, and Izzie decides to help Bailey with a project. Meanwhile, Richard makes a decision which sends all the attendings scrambling.
- The interns each react differently to a mass-casualty incident. Meanwhile, George crosses the professional line with Callie, Cristina asks Burke to keep quiet about their engagement, and Richard dons a new hairstyle.
- A toxic patient wreaks havoc. Meanwhile, Bailey opens the free clinic, but the lack of patients makes Izzie question her investment. Meredith's mother is admitted again, and Cristina makes Burke wait for an answer.
- A surgical team battles the clock as they try to save a boy encased in cement, Karev's situation with an ever-disintegrating Ava brings back painful memories that interfere with his judgment, Derek and Meredith have one last chance at their clinical trial.
- Owen faces a medical diagnosis that challenges more than he imagined. Meanwhile, Koracick begins to go stir crazy; and Maggie gets a not-so-subtle glimpse into Winston's background.
- Maggie is preoccupied with Winston while trying to treat a patient wounded in the Seattle protests. Meanwhile, Levi is tested by an emergency, and the doctors struggle to treat a patient who doesn't believe in COVID.
- As Thanksgiving, Christmas and New Year's pass, Miranda is visited by her father, William, who disapproves of her choices in life; meanwhile, Mark and Lexie must cope with the shocking arrival of a woman from his past, and Thatcher Grey questions the Chief's recent behavior as Meredith comes to his defense.
- During days 20 through 40 the staff continues toward acceptance. Meanwhile, Arizona takes a manipulative step to diagnose her pain patient and Hunt's amputee patient sinks into a deep depression.
- Thatcher is hospitalized with liver failure, and Meredith fights anger and guilt while deciding her responsibility. Sloan treats an octogenarian who wants an implant. Izzie's interference in Hunt's cancer case may have deadly consequences.
- After a burn victim unexpectedly dies in the midst of a chaotic ER, the Chief and board member Jennings interrogate the residents to find the culprit, as all the Mercy West and Seattle Grace residents defend their actions in an effort to save their jobs.
- A generous donation is offered to Seattle Grace by the parents of Arizona's 10-year-old patient. When his condition worsens, however, she finds herself with a conflict of interest. Meanwhile, Cristina tests her boundaries with Owen at the hospital and, adding insult to injury, Alex is left with all of Izzie's hospital bills to contend with.
- 2005– 1hTV-147.8 (1.1K)TV EpisodeAfter learning of Richard's drinking problem, Derek confronts him for the sake of his friend and the hospital, Izzie returns, hoping to reconcile with Alex, and tensions run high between Teddy, Cristina and Owen in the aftermath of Cristina's startling confession.
- It's Valentine's Day and the doctors must treat dozens of injured people after the roof collapses at a popular romantic restaurant; Derek tries to manage his busy schedule as Chief of Surgery; Meredith wrestles with her new duties as the Chief's wife; and Mark and Callie team up to convince Sloane to do the right thing for her baby.
- When Avery's grandfather comes to the ER, Webber's wish for a stress-free first day back is lost after the surgeon requests an awake surgery. Elsewhere, Cristina and Teddy attempt a hand-me-down lung transplant for a cancer survivor.
- When Teddy's patient seeks to end treatment and her life, she turns to Hunt for help. The situation triggers Hunt's memories of his life at war and his past relationship with Teddy. Meanwhile, Callie and Arizona have a difference in opinion on what their future holds, and Richard tries to adjust to his role as a surgeon.
- Cristina and Meredith's surgical skills are put to the ultimate test.
- Teddy asks Cristina to help with an OR patient.