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- Meet a child genius named Sheldon Cooper (already seen as an adult in The Big Bang Theory (2007)) and his family. Some unique challenges face Sheldon, who is socially impaired.
- A woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- The series follows Adrian Monk, a brilliant former San Francisco detective, who now consults the police as a private consultant whilst battling with an obsessive-compulsive disorder.
- The fractured domestic lives of a nihilistic mad scientist and his anxious grandson are further complicated by their inter-dimensional misadventures.
- Set almost 100 years after Captain Kirk's 5-year mission, a new generation of Starfleet officers sets off in the U.S.S. Enterprise-D on its own mission to go where no one has gone before.
- Covert black ops and espionage take a back seat to zany personalities and relationships between secret agents and drones.
- A heartwarming and emotional story about a unique set of triplets, their struggles, and their wonderful parents.
- A chronicle of the lives of a dysfunctional family who run an independent funeral home in Los Angeles.
- Bob Belcher runs a struggling burger shop with his wife and three children.
- Lifelong friends Eden and Dawn, one single and wanting a baby, the other already a mother, navigate challenges to their bond when Eden pursues pregnancy alone after a one-night stand.
- A 12-year-old boy and his best friend, a wise 28-year-old dog with magical powers, go on a series of surreal adventures in a remote future.
- A writer tries to juggle his career, his relationship with his daughter and his ex-girlfriend, as well as his appetite for beautiful women.
- A straight-laced propane salesman in Arlen, Texas tries to deal with the wacky antics of his family and friends, while also trying to keep his son in line.
- Boston Legal is a spin-off of the long-running David E. Kelley series The Practice (1997), following the exploits of former Practice character Alan Shore (James Spader) at the legal firm of Crane, Poole, and Schmidt.
- Teenage friends find their lives upended by the wonders and horrors of puberty.
- The lives and tragedies of the Braverman family tree.
- On a journey to find the cure for a Tatarigami's curse, Ashitaka finds himself in the middle of a war between the forest gods and Tatara, a mining colony. In this quest he also meets San, the Mononoke Hime.
- An eccentric fun-loving judge presides over an urban night court and all the silliness going on there.
- Phineas and Ferb invent, scheme, and stay one step ahead of their bratty sister. Meanwhile, their pet platypus plots against evil Dr. Doofenshmirtz.
- An actress raises her three daughters while juggling the pressures of working in Hollywood and being a single parent.
- A noble underachiever and a beautiful valedictorian fall in love the summer before she goes off to college.
- Mrs. Edna Garrett, housemother and dietitian at the Eastland School, teaches a group of girls in her charge how to solve those problems that every teenager has to face.
- The cases of an undercover police unit composed of young-looking officers specializing in youth crime.
- On the run in the year 1987, Bumblebee finds refuge in a junkyard in a small California beach town. On the cusp of turning 18 and trying to find her place in the world, Charlie Watson discovers Bumblebee, battle-scarred and broken.
- Fifteen-year-old Ben Tennyson must utilize the Omnitrix yet again in order to locate his missing Grandpa Max, accompanied by his cousin Gwen and former enemy Kevin 11.