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- Meet a child genius named Sheldon Cooper (already seen as an adult in The Big Bang Theory (2007)) and his family. Some unique challenges face Sheldon, who is socially impaired.
- A drama centered on the personal and professional lives of five surgical interns and their supervisors.
- A woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- The series follows Adrian Monk, a brilliant former San Francisco detective, who now consults the police as a private consultant whilst battling with an obsessive-compulsive disorder.
- Five friends with big egos and small brains are the proprietors of an Irish pub in Philadelphia.
- Comedy series following the exploits of Det. Jake Peralta and his diverse, lovable colleagues as they police the NYPD's 99th Precinct.
- A famous "psychic" outs himself as a fake, and starts working as a consultant for the California Bureau of Investigation so he can find "Red John", the madman who killed his wife and daughter.
- A father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- Bob Belcher runs a struggling burger shop with his wife and three children.
- The doctors who work in the ER at the County General Hospital in Chicago grapple with ups and downs in their personal and professional lives while trying to give apt medical care to their patients.
- Enforcing his own brand of justice, U.S. Marshal Raylan Givens, a strong-willed, quiet law-man haunted by his past, returns to his native town to see that justice is served to those in need.
- A dramedy centering around the relationship between a thirtysomething single mother and her teen daughter living in Stars Hollow, Connecticut.
- An elite unit, led by an ex-homicide cop, which is linked to the Miami-Dade Police Department, uses all possible resources and skills at their disposal to solve complex crimes in cross-cultural Miami.
- A writer tries to juggle his career, his relationship with his daughter and his ex-girlfriend, as well as his appetite for beautiful women.
- Drama about the pioneers of the science of human sexuality whose research touched off the sexual revolution.
- A family man struggles to gain a sense of cultural identity while raising his kids in a predominantly white, upper-middle-class neighborhood.
- Project sees Keegan-Michael Key and Jordan Peele in front of a live studio audience bantering about a topic weaved between filmed shorts and sketches.
- Three middle-aged best friends from Los Angeles are flying to Paris when their plane makes an emergency landing in Cleveland. Realizing that all the norms from Los Angeles don't apply anymore, they decide to celebrate a city that values real women and stay where they're still considered hot.
- The adventurous life of Cricket Green, a country boy who moves with his family from their rural farm to a modern metropolis.
- A fool for love becomes an accidental celebrity only to lose it all.
- A 20-something bachelor bartender becomes an unlikely parent when an ex-girlfriend leaves a baby girl on his doorstep.
- It's 1949 Los Angeles, the city is run by gangsters and a malicious mobster, Mickey Cohen. Determined to end the corruption, John O'Mara assembles a team of cops, ready to take down the ruthless leader and restore peace to the city.
- In this spin-off of Friends (1994), Joey Tribbiani moves to Los Angeles to pursue his acting career.
- When Holly's father is transferred to Japan, she is sent to live with her big sister Valerie in New York City, turning Valerie's life upside down.
- A 13-year-old orphan becomes an NBA superstar after trying on a pair of sneakers with the faded initials "MJ" inside them.