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- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglWhile the man with the bomb lodged in his chest remains in Burke's OR with Meredith's hand in the cavity, Bailey's injured husband remains in Derek's. Meanwhile, Bailey's distress puts her unborn baby at risk.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglRichard is determined to discover the guilty party, and punishes the interns by making them arrange a prom for his niece. Meanwhile, Callie presses George about his feelings, and Derek and Meredith have to make a decision about Doc.
- DirectorAdam ArkinStarsEllen PompeoSandra OhKatherine HeiglAn unconscious Meredith interacts with some ghosts from her past while Richard, Burke and Bailey devise an unusual method of reviving her. A despondent Cristina leaves during her shift, and Derek speaks his mind to Meredith's mother.
- DirectorMichael GrossmanStarsEllen PompeoSandra OhKatherine HeiglAn accident in the ER bay leaves two paramedics fighting for their lives, and a third who refuses Bailey's care. Meanwhile, Alex juggles two women, and Lexie begins to bond with a patient.
- DirectorJessica YuStarsEllen PompeoSandra OhKatherine HeiglTragedy abounds for everyone at Seattle Grace as they all continue in efforts to get the paramedic out of the overturned ambulance, stop the bleeding of a man who won't quit, and a bigot with a Nazi tattoo on his stomach. On the personal side, Rebecca returns to spend time with Alex, Miranda's husband finds it harder to wait for her while she's in surgery, and Cristina still tries to get on Hahn's good side, even though Bailey has put her elsewhere.
- DirectorAllison Liddi-BrownStarsEllen PompeoSandra OhKatherine HeiglMeredith and Miranda each cross a line, William Dunn regrets his decision and Izzie finally confronts what Denny's appearance means.
- DirectorEdward OrnelasStarsEllen PompeoSandra OhKatherine HeiglOwen's PTSD endangers Cristina, Izzie's illness leaves the residents dealing with guilt and anger - at her expense, and Derek's fear causes him to persevere for Meredith's answer.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglIzzie's memory problems panic Alex, the team takes care of a John Doe who was hit by a bus, Bailey rethinks her pediatrics fellowship, and the hospital endures losses.
- DirectorEdward OrnelasStarsEllen PompeoSandra OhKatherine HeiglCovering days one through 13, everyone at Seattle Grace fights to save Izzie and George's lives and then deals with the aftermath. Elsewhere, Hunt treats a double amputation, and Arizona has a teen with painful growth spurts.
- DirectorStephen CraggStarsEllen PompeoSandra OhJustin ChambersSeattle Grace Hospital is hit with a crisis like no other in its history.
- DirectorRob CornStarsEllen PompeoSandra OhJustin ChambersCristina and Meredith's surgical skills are put to the ultimate test.
- DirectorTony PhelanStarsEllen PompeoSandra OhJustin ChambersIn a series first, the music that has been at the heart of the show and been beloved by fans comes to life for Grey's Anatomy: The Music Event. A cataclysmic event rattles the doctors of Seattle Grace to the core, as Callie, on the verge of an enormous life-changing moment with Arizona, envisions her hospital and friends as it has never-been-seen before. "Chasing Cars" (Snow Patrol), "How to Save a Life" (The Fray) and "The Story" (Brandi Carlile) are among the songs performed by the cast.
- DirectorAllison Liddi-BrownStarsEllen PompeoSandra OhJustin ChambersTeddy is called away on another case, as Henry is brought in for surgery.
- DirectorRon UnderwoodStarsEllen PompeoSandra OhJustin ChambersTeddy asks Cristina to help with an OR patient.
- DirectorRob CornStarsEllen PompeoSandra OhJustin ChambersAs Meredith, Cristina, Derek, Mark, Lexie, and Arizona face the aftermath of their accident, the doctors back at the hospital face the future that seems to be taking them all in different directions.
- DirectorRob CornStarsEllen PompeoSandra OhJustin ChambersMonths after the plane crash, the doctors at Seattle continue to try and find a new sense of normalcy. With a new set of interns to put through the ringer, the new fellows and attendings get used to their roles while Cristina adjusts to her new life in Minnesota. But the life of one doctor hangs in the balance and it's clear that Seattle Grace Mercy West is not the same.
- DirectorBill D'EliaTony PhelanStarsEllen PompeoSandra OhJustin ChambersCristina must head to Zurich soon but she is unprepared to leave behind her life in Seattle. Fear runs amok throughout the hospital as an explosion in a shopping mall results in a mass casualty situation.
- DirectorChris HaydenStarsEllen PompeoJustin ChambersChandra WilsonJackson struggles to understand April's decision; Ben & Bailey discuss their future; a patient revisits Callie; Amelia tries to deal with her past.