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- CreatorBill LawrenceStarsZach BraffDonald FaisonSarah ChalkeIn the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoAspiring film actress Penny moves into a Pasadena apartment across the hall from brilliant, but socially awkward, physicists Sheldon Cooper and Leonard Hofstadter and shows them how little they know about life outside of the lab.
- CreatorAllison M. GibsonStarsReba McEntireJoAnna Garcia SwisherSteve HoweyReba McEntire stars as the titular character in this smash sitcom about a single mom of three, navigating life in a Houston suburb.
- CreatorClaudia LonowStarsJenna ElfmanJon FosterAshley Jensen37-year-old Billie breaks up with her boss at the newspaper and gets pregnant by 22-year-old Zack, who moves into her apartment. They both have their pals.
- CreatorEd YeagerStarsJay MohrPaula MarshallRyan MalgariniNewly divorced after fifteen years of marriage, Gary Brooks, a painting contractor, strives to balance work, shared custody of his two children, a controlling ex-wife, and his foxy new girlfriend.
- CreatorTracy NewmanJonathan StarkStarsJim BelushiCourtney Thorne-SmithLarry Joe CampbellA television show centered around a macho everyman, his loving wife, and their three precocious children.
- CreatorShonda RhimesMichelle LirtzmanStarsEllen PompeoChandra WilsonJames Pickens Jr.A drama centered on the personal and professional lives of five surgical interns and their supervisors.
- CreatorShonda RhimesStarsKate WalshPaul AdelsteinKaDee StricklandA spin-off of the medical drama "Grey's Anatomy" centering on the life of neonatal surgeon Addison Montgomery.
- CreatorRob McElhenneyGlenn HowertonStarsCharlie DayGlenn HowertonRob McElhenneyFive friends with big egos and small brains are the proprietors of an Irish pub in Philadelphia.
- CreatorTom HertzStarsPatrick WarburtonMegyn PriceOliver HudsonTwo couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment, and marriage.
- CreatorJames BergStan ZimmermanStarsNicole SullivanRichard RuccoloTisha CampbellA frazzled working mother starts a garage band with her neighbor and a female postal worker.
- CreatorDanny JacobsonKenny SchwartzRick WienerStarsTraylor HowardRyan ReynoldsRichard RuccoloThree twenty-somethings share a Boston apartment and hang around (and work) at a pizza place.
- CreatorFernando GaitánSilvio HortaStarsAmerica FerreraEric MabiusTony PlanaSmart but wholesome Betty embraces her unique appearance and independent attitude in the cutthroat world of New York fashion.
- CreatorJoanna JohnsonStarsFaith FordKelly RipaMacey CruthirdThey're sisters, but blood may be the only thing they have in common. When Faith, a soap opera diva, is killed off her show, "The Sacred and the Sinful," she flees the tabloids by moving to the suburbs with her sister, Hope's, family.
- CreatorJosh H. EttingDavid GarrettJamie KennedyStarsFran DrescherRyan McPartlinMisti TrayaA mother of two ends up falling in love with a man half her age and tries to make him part of the family.
- CreatorDavid E. KelleyStarsCalista FlockhartGreg GermannJane KrakowskiFollows the personal and professional life of lawyer Ally.
- CreatorDavid E. KelleyStarsJames SpaderWilliam ShatnerCandice BergenBoston Legal is a spin-off of the long-running David E. Kelley series The Practice (1997), following the exploits of former Practice character Alan Shore (James Spader) at the legal firm of Crane, Poole, and Schmidt.
- CreatorDavid CroftJeremy LloydStarsGorden KayeCarmen SilveraVicki MichelleIn France during World War II, René Artois runs a small café where Resistance fighters, Gestapo men, German Army officers and escaped Allied POWs interact daily, ignorant of one another's true identity or presence, exasperating René.
- CreatorTracy GambleStarsKatey SagalKaley CuocoAmy DavidsonThe Hennessy clan -- mother Cate, daughters Bridget and Kerry, and son Rory -- look to one another for guidance and support after the death of Paul, the family patriarch. Cate's parents lend a hand.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorMarc CherryStarsTeri HatcherFelicity HuffmanMarcia CrossSecrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- CreatorChuck LorreDottie Dartland ZicklinStarsJenna ElfmanThomas GibsonJoel MurrayA free-spirited yoga instructor finds true love in a conservative lawyer and they get married on the first date. Though they are polar opposites, he fulfills her need of stability and she fulfills his need of optimism.
- CreatorDoug EllinStarsKevin ConnollyAdrian GrenierKevin DillonFilm star, Vince Chase, navigates the vapid terrain of Los Angeles with a close circle of friends and his trusty agent.