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- DirectorJohn S. RobertsonStarsJohn BarrymoreMartha MansfieldBrandon HurstDr. Henry Jekyll experiments with scientific means of revealing the hidden, dark side of man and releases a murderer from within himself.
- DirectorFritz LangStarsBrigitte HelmAlfred AbelGustav FröhlichIn a futuristic city sharply divided between the working class and the city planners, the son of the city's mastermind falls in love with a working-class prophet who predicts the coming of a savior to mediate their differences.
- DirectorJohn FordStarsRonald ColmanHelen HayesRichard BennettA medical researcher is sent to a plague outbreak, where he has to decide priorities for the use of a vaccine.
- DirectorErle C. KentonStarsCharles LaughtonBela LugosiRichard ArlenA mad doctor conducts ghastly genetic experiments on a remote island in the South Seas, much to the fear and disgust of the shipwrecked sailor who finds himself trapped there.
- DirectorJames WhaleStarsClaude RainsGloria StuartWilliam HarriganA scientist finds a way of becoming invisible, but in doing so, he becomes murderously insane.
- DirectorWilliam DieterleStarsPaul MuniJosephine HutchinsonAnita LouiseThe biography of the pioneering French microbiologist who helped revolutionize agriculture and medicine.
- DirectorAnatole LitvakStarsEdward G. RobinsonHumphrey BogartClaire TrevorA brilliant Park Avenue doctor becomes a criminal in order to do research into the criminal mind.
- DirectorHarold S. BucquetStarsSpencer TracyKatharine HepburnLucille BallIn Washington, D.C. during World War II, Jamie Rowan enters into a loveless marriage with scientist Pat Jamieson and becomes his assistant. Struggles bring them closer together.
- DirectorIrving PichelStarsJohn ArcherWarner AndersonTom Powers"Destination Moon", tells the tale of when Doctor Charles Cargraves and retired General Thayer approach Jim Barnes, the head of his own aviation construction firms to help build a rocket that will take them to the moon.
- DirectorRalph NelsonStarsCliff RobertsonClaire BloomLilia SkalaAn intellectually disabled man undergoes an experiment that gives him the intelligence of a genius.
- DirectorRobert WiseStarsJames OlsonArthur HillDavid WayneTop scientists work feverishly in a secret, state-of-the-art laboratory to discover what killed the citizens of a small town and how the deadly contagion can be stopped.
- DirectorSaul BassStarsNigel DavenportMichael MurphyLynne FrederickSuddenly, desert ants form a group intelligence and wage war on the humans. It's up to a couple of scientists and a girl to stop them
- DirectorMike HodgesStarsGeorge SegalJoan HackettRichard DysartHoping to cure his violent seizures, a man agrees to a series of experimental microcomputers inserted into his brain but inadvertently discovers that violence now triggers a pleasurable response to his brain.
- DirectorRalph NelsonStarsRock HudsonBarbara CarreraDiane LaddA scientist (Rock Hudson) doing experiments on a human fetus discovers a method to accelerate the fetus into a mature adult in just a few days. All is not well though as the child begins to exhibit some horrific tendencies.
- DirectorDon TaylorStarsBurt LancasterMichael YorkNigel DavenportA shipwrecked survivor discovers a remote island owned by a crazed scientist who is carrying out sinister experiments on the island's inhabitants.
- DirectorRichard FranklinStarsSusan PenhaligonRobert HelpmannRod MullinarA comatose hospital patient harasses and kills through his powers of telekinesis to claim his private nurse as his own.
- DirectorDavid LynchStarsAnthony HopkinsJohn HurtAnne BancroftA Victorian surgeon rescues a heavily disfigured man who is mistreated while scraping a living as a side-show freak. Behind his monstrous façade, there is revealed a person of kindness, intelligence and sophistication.
- DirectorFranklin J. SchaffnerStarsLesley-Anne DownFrank LangellaMaurice RonetEgyptologist Erica Baron finds more than she bargained for during her long-planned trip to The Land of the Pharoahs: murder, theft, betrayal, love, and a mummy's curse.
- DirectorDavid CronenbergStarsJennifer O'NeillStephen LackPatrick McGoohanA scientist trains a man with an advanced telepathic ability called "scanning" to stop a dangerous Scanner with extraordinary psychic powers from waging war against non scanners.
- DirectorCarroll BallardStarsCharles Martin SmithBrian DennehyZachary IttimangnaqA government researcher, sent to research the "menace" of wolves in the north, learns about the true beneficial and positive nature of the species.
- DirectorIvan ReitmanStarsBill MurrayDan AykroydSigourney WeaverThree parapsychologists forced out of their university funding set up shop as a unique ghost removal service in New York City, attracting frightened yet skeptical customers.
- DirectorStewart RaffillStarsMichael ParéNancy AllenEric ChristmasA United States Navy destroyer escort participates in a Navy "invisibility" experiment that inadvertently sends two sailors forty years into the future.
- DirectorFred SchepisiStarsTimothy HuttonLindsay CrouseJohn LoneA prehistoric Neanderthal man found frozen in ice is revived by an arctic exploration team, who then attempt to use him for their own scientific means.
- DirectorRobert ZemeckisStarsMichael J. FoxChristopher LloydLea ThompsonMarty McFly, a 17-year-old high school student, is accidentally sent 30 years into the past in a time-traveling DeLorean invented by his close friend, the maverick scientist Doc Brown.
- DirectorMartha CoolidgeStarsVal KilmerStacy PeraltaDaniel AdesAn uptight teenage prodigy enters a top engineering college, but feels awkward among the freewheeling students. When a professor aims to turn their laser project into a military weapon, he and his offbeat roommate plot to ruin the plan.
- DirectorLeonid MenakerStarsOlgert KrodersIgor VasilevValentina TitovaProfessor Dowell and his assistant surgeon Dr. Kern are working on the resurrection of the dead. Dr. Kern kills Dowell in a set up car accident. Professor Dowell's head is now kept alive and used by Dr. Kern for extraction of scientific secrets. Next - the living head of a killed woman gets a body of a young woman. That body belongs to the girlfriend of Dowell's son. Dr. Kern is anxious to announce himself as the inventor. But Dowell's son helps his father's head to get in front of the cameras. The head of professor Dowell tells all and dies.
- DirectorStuart GordonStarsJeffrey CombsBruce AbbottBarbara CramptonAfter an odd new medical student arrives on campus, a dedicated local and his girlfriend become involved in bizarre experiments centering around the re-animation of dead tissue.
- DirectorJoe DanteStarsDennis QuaidMartin ShortMeg RyanA test pilot is miniaturized in a secret experiment, and accidentally injected into a hapless store clerk.
- DirectorMichael AptedStarsSigourney WeaverBryan BrownJulie HarrisThe story of Dian Fossey, a scientist who came to Africa to study the vanishing mountain gorillas, and later fought to protect them.
- DirectorVladimir BortkoStarsEvgeniy EvstigneevVladimir TolokonnikovBoris PlotnikovIn the wake of the Russian revolution, Professor Preobrazhensky rescues a starving dog from the gutter, and attempts to transform him into a man. Based on Mikhail Bulgakov's novel of the same name.
- DirectorJoe JohnstonStarsRick MoranisMatt FrewerMarcia StrassmanThe scientist father of a teenage girl and boy accidentally shrinks his and two other neighborhood teens to the size of insects. Now the teens must fight diminutive dangers as the father searches for them.
- DirectorRobert ZemeckisStarsMichael J. FoxChristopher LloydLea ThompsonAfter visiting 2015, Marty McFly must repeat his visit to 1955 to prevent disastrous changes to 1985...without interfering with his first trip.
- DirectorIvan ReitmanStarsBill MurrayDan AykroydSigourney WeaverThe discovery of a massive river of ectoplasm and a resurgence of spectral activity allows the staff of Ghostbusters to revive the business.
- DirectorPenny MarshallStarsRobert De NiroRobin WilliamsJulie KavnerThe victims of an encephalitis epidemic many years ago have been catatonic ever since, but now a new drug offers the prospect of reviving them.
- DirectorRobert ZemeckisStarsMichael J. FoxChristopher LloydMary SteenburgenStranded in 1955, Marty McFly learns about the death of Doc Brown in 1885 and must travel back in time to save him. With no fuel readily available for the DeLorean, the two must figure how to escape the Old West before Emmett is murdered.
- DirectorJoel SchumacherStarsKiefer SutherlandKevin BaconJulia RobertsFive medical students experiment with "near death" experiences, until the dark consequences of past tragedies begin to jeopardize their lives.
- DirectorGeorge MillerStarsNick NolteSusan SarandonPeter UstinovLorenzo Odone, a Virginia 5-year-old, develops a degenerative nerve disease so rare that nobody is working on a cure, so his parents decide to immerse themselves in research and tackle the problem themselves.
- DirectorJohn McTiernanStarsSean ConneryLorraine BraccoJosé WilkerIn the beautiful and dangerous Amazon rainforest, dissimilar people must make their choices between business, science, and love.
- DirectorRandal KleiserStarsRick MoranisMarcia StrassmanRobert OliveriThe Szalinski family is back, this time hilarious disaster strikes when an experiment causes their new toddler son to grow many stories tall.
- DirectorSteven SpielbergStarsSam NeillLaura DernJeff GoldblumA pragmatic paleontologist touring an almost complete theme park on an island in Central America is tasked with protecting a couple of kids after a power failure causes the park's cloned dinosaurs to run loose.
- DirectorKenneth BranaghStarsRobert De NiroKenneth BranaghHelena Bonham CarterWhen the brilliant but unorthodox scientist Dr. Victor Frankenstein rejects the artificial man that he has created, the Creature escapes and later swears revenge.
- DirectorFred SchepisiStarsTim RobbinsMeg RyanWalter MatthauA mechanic romances the mathematician niece of physicist Albert Einstein, with help from him and his friends.
- DirectorIvan ReitmanStarsArnold SchwarzeneggerDanny DeVitoEmma ThompsonAs part of a fertility research project, a male scientist agrees to carry a pregnancy in his own body.
- DirectorLarry ShawStarsJoanna KernsGregory HarrisonMax GailBased on the provocative best-selling novel, a brilliant scientist finds the hidden link that can save countless lives, but when a crazed killer uses the same information to play God, millions are at risk. Dr. Jennifer Kessler is the one person who stands in the way of ultimate medical disaster. After witnessing one, then dozens of patients at her hospital mysteriously and unexpectedly die, her search for the truth leads her through a bizarre world of intrigue, passion, and controversial secret medical research. As Dr. Kessler races against the clock to find a way to stop the catastrophe, she finds herself up against an imposing and terrifying conspiracy implicating the entire U.S. insurance and medical system in the process.
- DirectorRobert LongoStarsKeanu ReevesDolph LundgrenDina MeyerA data courier, literally carrying a data package inside his head, must deliver it before he dies from the burden or is killed by the Yakuza.
- DirectorWolfgang PetersenStarsDustin HoffmanRene RussoMorgan FreemanArmy doctors struggle to find a cure for a deadly virus spreading throughout a California town that was brought to America by an African monkey.
- DirectorTerry GilliamStarsBruce WillisMadeleine StoweBrad PittIn a future world devastated by disease, a convict is sent back in time to gather information about the man-made virus that wiped out most of the human population on the planet.
- DirectorArmand MastroianniStarsNicollette SheridanWilliam DevaneStephen CaffreyWho could have deliberately released a rare and deadly African plague that is now spreading uncontrollably throughout America's largest urban areas? A lone determined doctor desperately and fearlessly searches for the truth, but she soon finds herself targeted for death as well. With time running out to save human kind, Dr. Marissa Blumenthal discovers that the strange disease may have actually been unleashed by the medical establishment itself.
- DirectorStephen FrearsStarsJulia RobertsJohn MalkovichGeorge ColeA housemaid falls in love with Dr. Henry Jekyll and his darkly mysterious counterpart, Mr. Edward Hyde.
- DirectorAndrew DavisStarsKeanu ReevesMorgan FreemanRachel WeiszTwo researchers in a green alternative energy project are put on the run when they are framed for murder and treason.
- DirectorJan de BontStarsHelen HuntBill PaxtonCary ElwesTwo storm chasers on the brink of divorce must work together to create an advanced weather alert system by putting themselves in the cross-hairs of extremely violent tornadoes.
- DirectorJon TurteltaubStarsJohn TravoltaKyra SedgwickForest WhitakerAn ordinary man sees a bright light descend from the sky, and discovers he now has super-intelligence and telekinesis.
- DirectorJohn FrankenheimerRichard StanleyStarsDavid ThewlisMarlon BrandoVal KilmerAfter being rescued and brought to an island, a man discovers that its inhabitants are experimental animals being turned into strange-looking humans, all of it the work of a visionary doctor.
- DirectorDavid TwohyStarsCharlie SheenLindsay CrouseRichard SchiffZane, an astronomer, discovers intelligent alien life. But the aliens are keeping a deadly secret, and will do anything to stop Zane from learning it.
- DirectorTom ShadyacStarsEddie MurphyJada Pinkett SmithJames CoburnGrossly overweight yet good-hearted professor Sherman Klump takes a special chemical that turns him into the slim but obnoxious Buddy Love.
- DirectorGus Van SantStarsRobin WilliamsMatt DamonBen AffleckWill Hunting, a janitor at M.I.T., has a gift for mathematics, but needs help from a psychologist to find direction in his life.
- DirectorRobert ZemeckisStarsJodie FosterMatthew McConaugheyTom SkerrittDr. Ellie Arroway, after years of searching, finds conclusive radio proof of extraterrestrial intelligence, sending plans for a mysterious machine.
- DirectorJim AbrahamsStarsMeryl StreepFred WardSeth AdkinsThe story of one woman's struggle against a narrow-minded medical establishment.
- DirectorPaul W.S. AndersonStarsLaurence FishburneSam NeillKathleen QuinlanA rescue crew is tasked with investigating the mysterious reappearance of a spaceship that had been lost for seven years.
- DirectorNeill FearnleyStarsJeff FaheyTahnee WelchMichael IronsideAwakening from a 15-year coma, scientist Johnny Dalton (Fahey) discovers that his life has been illusory and that he is merely a clone of the real Dr. Dalton. With the help of rebel leader Nikki Holland (Welch), Dalton sets out to find his maker in a futuristic society fraught with danger and secrecy.
- DirectorLes MayfieldStarsRobin WilliamsMarcia Gay HardenChristopher McDonaldAn absent-minded professor discovers "flubber," a rubber-like super-bouncy substance.
- DirectorRoger DonaldsonStarsPierce BrosnanLinda HamiltonJamie Renée SmithA volcanologist arrives at a countryside town recently named the second-most desirable place to live in America, and discovers that a nearby long-dormant volcano may awaken at any moment.
- DirectorTom McLoughlinStarsKelly McGillisJason GedrickLarry HagmanA researcher's life is in danger when she discovers a secret cloning operation.
- DirectorAriel ZeitounStarsJudith GodrècheAure AtikaGérard DepardieuA shy French anthropologist who happens to be secretly in love with her college superior, chooses "bimbos" as the subject of her thesis. She becomes one of them in order to do that, and the professor she loves falls for her new identity.
- DirectorTodd HollandStarsRichard DreyfussJenna ElfmanNatasha LyonneAn anthropologist creates a fictitious lost New Guinea tribe using his family members to cover-up for his misuse of grant monies.
- DirectorDarren AronofskyStarsSean GulletteMark MargolisBen ShenkmanA paranoid mathematician searches for a key number that will unlock the universal patterns found in nature.
- DirectorMimi LederStarsRobert DuvallTéa LeoniElijah WoodA comet is discovered to be on a collision course with Earth. As doomsday nears, the human race prepares for the worst.
- DirectorBill NortonStarsAdam ArkinJoely FisherGiancarlo EspositoA chemical engineer, who recently moved to town, struggles to find a way to kill a deadly new variant of Cryptosporidium that has infiltrated the town's water supply, causing people who drink it to die of thirst.
- DirectorChris ColumbusStarsRobin WilliamsEmbeth DavidtzSam NeillAn android endeavors to become human as he gradually acquires emotions.
- DirectorJoe JohnstonStarsJake GyllenhaalChris CooperLaura DernThe true story of Homer Hickam, a coal miner's son who was inspired by the first Sputnik launch to take up rocketry against his father's wishes.
- DirectorJan de BontStarsLiam NeesonCatherine Zeta-JonesOwen WilsonDr Marrow enlists Theo, Luke and Nell for a study of sleep disorders at the Hill House. As soon as the terrifying truth about the mansion is revealed, everyone is found fighting for their lives.
- DirectorStephen SommersStarsBrendan FraserRachel WeiszJohn HannahAt an archaeological dig in the ancient city of Hamunaptra, an American serving in the French Foreign Legion accidentally awakens a mummy who begins to wreak havoc as he searches for the reincarnation of his long-lost love.
- DirectorAntony HoffmanStarsVal KilmerCarrie-Anne MossTom SizemoreAstronauts, and their robotic dog AMEE (Autonomous Mapping Evaluation and Evasion), search for solutions to save a dying Earth by searching on Mars, only to have the mission go terribly awry.
- DirectorPaul VerhoevenStarsKevin BaconElisabeth ShueJosh BrolinA brilliant scientist's discovery renders him invisible, but transforms him into an omnipotent, dangerous megalomaniac.
- DirectorJeff BlecknerStarsPaige TurcoJason BegheKenneth MarsTwo experts on viruses tracks down some contagious people all across the world. But it's just a matter of time before L.A. vill be exposed to the virus.
- DirectorAnthony HickoxStarsWilliam HurtNatascha McElhonePeter WellerIn 1986, David Whitman came home, contaminated his wife and child, and watched them die. Years later, he leads a hazmat team investigating an industrial accident near Budapest. One contaminated man escaped. Terrorist expert Holly Anderson is part of a unit which operates on the premise that the contaminated man is a terrorist murdering his victims. Whitman, on the other hand, believes the contaminated man to be an innocent victim. Either way, the contaminated man must be found, because after he touches people, they live only a few minutes.
- DirectorWilliam R. GreenblattStarsEsai MoralesJames MarshallYancy ButlerAfter his wife is killed researching a deadly virus, a doctor, out of anger and guilt, infects himself with the virus and threatens the world.
- DirectorSteven SpielbergStarsHaley Joel OsmentJude LawFrances O'ConnorA highly advanced robotic boy longs to become "real" so that he can regain the love of his human mother.
- DirectorWilliam A. GrahamStarsChad LoweKelly RutherfordSean Patrick FlaneryAn ambitious medical researcher discovers a mold that he believes could be the foundation of a miracle cure for degenerative diseases.
- DirectorOliver HirschbiegelStarsMoritz BleibtreuChristian BerkelOliver StokowskiFor two weeks, 20 male participants are hired to play prisoners and guards in a prison. The "prisoners" have to follow seemingly mild rules, and the "guards" are told to retain order without using physical violence.
- DirectorSimon WellsStarsGuy PearceYancey AriasMark AddyHoping to alter the events of the past, a 19th century inventor instead travels 800,000 years into the future, where he finds humankind divided into two warring races.
- DirectorLynn Hershman LeesonStarsTilda SwintonJeremy DaviesJames UrbaniakTilda Swinton plays four roles in this award-winning film about Rosetta Stone and her three Self-Replicating Automatons, which she cloned from her own D.N.A.
- DirectorBryan GoeresStarsDean CainBrian BosworthMimi KuzykA reporter on the trail of a series of homicides uncovers a shady plot featuring an experimental drug.
- DirectorRichard DonnerStarsPaul WalkerGerard ButlerBilly ConnollyA group of archaeologists get embroiled in an adventure where they must travel back in time to 14th Century France, to save their professor before the French battle the English at Castlegard. If they fail, they won't be able to return.
- DirectorUli EdelStarsThomas GibsonKatherine HeiglSimon BossellAfter his wife is brutally murdered, a policeman transfers to patrol duty at a college, only to discover that the now-executed murderder may be brought back to life as part of a professor's experiment.
- DirectorJoseph SargentStarsCliff McMullenYasiin BeyLuray CooperA dramatization of the relationship between heart surgery pioneers Alfred Blalock and Vivien Thomas.
- DirectorRoland EmmerichStarsDennis QuaidJake GyllenhaalEmmy RossumJack Hall, paleoclimatologist, must make a daring trek from Washington, D.C. to New York City to reach his son, trapped in the cross-hairs of a sudden international storm which plunges the planet into a new Ice Age.
- DirectorAlex ProyasStarsWill SmithBridget MoynahanBruce GreenwoodIn 2035, a technophobic cop investigates a crime that may have been perpetrated by a robot, which leads to a larger threat to humanity.
- DirectorFrank OzStarsNicole KidmanBette MidlerMatthew BroderickThe secret to a Stepford wife lies behind the doors of the Men's Association.
- DirectorMichael BayStarsScarlett JohanssonEwan McGregorDjimon HounsouA man living in a futuristic sterile colony begins to question his circumscribed existence when his friend is chosen to go to the Island, the last uncontaminated place on earth.
- DirectorJohn MaddenStarsGwyneth PaltrowAnthony HopkinsHope DavisThe daughter of a brilliant but mentally disturbed mathematician, recently deceased, tries to come to grips with her possible inheritance: his insanity. Complicating matters are one of her father's ex-students, who wants to search through his papers, and her estranged sister, who shows up to help settle his affairs.
- DirectorJason ReitmanStarsAaron EckhartCameron BrightMaria BelloSatirical comedy follows the machinations of Big Tobacco's chief spokesman, Nick Naylor, who spins on behalf of cigarettes while trying to remain a role model for his 12-year old son.
- DirectorRob CohenStarsJosh LucasJessica BielJamie FoxxDeeply ensconced in a top-secret military program, three pilots struggle to bring an artificial intelligence program under control before it initiates the next world war.
- DirectorFinn TaylorStarsJoseph FiennesWinona RyderDavid ArquetteTo investigate bizarre insurance claims that transpired in either accidents, death or both, a former cop and an insurance investigator travel throughout the country to look at the cases up close.
- DirectorTibor TakácsStarsKristy SwansonJudd NelsonDavid SelbyAn atomic research experiment goes awry in St. Louis, Missouri unleashing not only a big black hole, but also a creature from beyond that feeds on electricity through the streets of this Midwest city.
- DirectorOliver HirschbiegelStarsNicole KidmanDaniel CraigJeremy NorthamAs a Washington, D.C. psychiatrist unearths the origin of an alien epidemic, she also discovers her son might be the only way it can be stopped.
- DirectorFrancis LawrenceStarsWill SmithAlice BragaCharlie TahanYears after a plague kills most of humanity and transforms the rest into monsters, the sole survivor in New York City struggles valiantly to find a cure.
- DirectorMarc AbrahamStarsGreg KinnearLauren GrahamAlan AldaRobert Kearns takes on the Detroit automakers who he claims stole his idea for the intermittent windshield wiper.
- DirectorJon AmielStarsPaul BettanyJennifer ConnellyIan KellyTorn between faith and science, and suffering hallucinations, English naturalist Charles Darwin struggles to complete 'On the Origin of Species' and maintain his relationship with his wife.
- DirectorAlejandro AmenábarStarsRachel WeiszMax MinghellaOscar IsaacA historical drama set in Roman Egypt, concerning a slave who turns to the rising tide of Christianity in the hope of pursuing freedom while falling in love with his mistress, the philosophy and mathematics professor Hypatia of Alexandria.