Violence ensues after an extraterrestrial race forced to live in slum-like conditions on Earth finds a kindred spirit in a government agent exposed to their biotechnology.
Dr Robert Neville has developed an experimental vaccine which makes him the only immune survivor of a biological catastrophe. A gang of homicidal mutants blame science for their condition and attempt to kill him.
A game designer on the run from assassins must play her latest virtual reality creation with a marketing trainee to determine if the game has been damaged.