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- CreatorBruce HelfordStarsCharlie SheenShawnee SmithNoureen DeWulfEx-baseball-player Charlie is an anger-management therapist who has small-group sessions at home, an OCD teen daughter, an ex-wife, and a sex-buddy/therapist.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoAspiring film actress Penny Teller moves into a Pasadena apartment across the hall from brilliant, but socially awkward, physicists Sheldon Cooper and Leonard Hofstadter and shows them how little they know about life outside of the lab.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorDavid ShoreStarsHugh LaurieOmar EppsRobert Sean LeonardUsing a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- CreatorMeredith StiehmStarsKathryn MorrisDanny PinoJohn FinnThe Philadelphia homicide squad's lone female detective finds her calling when she's assigned "cold cases," older crimes that have never been solved.
- CreatorBlake MastersDick WolfStarsCorey StollRachel TicotinAlfred MolinaLos Angeles police detectives investigate crimes and district attorneys prosecute the offenders.
- CreatorAli LeRoiChris RockStarsTerry CrewsTichina ArnoldTequan RichmondA young African-American teen attempts to survive with his dysfunctional family and his all-white school in the 1980s.
- CreatorDon ReoDamon WayansStarsDamon WayansTisha CampbellGeorge Gore IIMichael Kyle longs for a traditional life, but his day-trader wife Janet, gangsta rap-worshipping son Michael Jr., and brooding daughters Claire and Kady make his dream just that ... a dream.
- CreatorAlfred GoughMiles MillarStarsTom WellingMichael RosenbaumAllison MackA young Clark Kent struggles to find his place in the world as he learns to harness his alien powers for good and deals with the typical troubles of teenage life in Smallville, Kansas.
- CreatorChris FedakJosh SchwartzStarsZachary LeviYvonne StrahovskiJoshua GomezWhen a computer geek inadvertently downloads critical government secrets into his brain, both the CIA and the NSA assign an agent to protect him and exploit his newfound skills.
- CreatorMark RobertsStarsBilly GardellMelissa McCarthyReno WilsonA couple meets at an Overeaters' Anonymous meeting.
- CreatorEric KripkeStarsJared PadaleckiJensen AcklesJim BeaverTwo brothers follow their father's footsteps as hunters, fighting evil supernatural beings of many kinds, including monsters, demons, and gods that roam the earth.
- CreatorFrank DarabontStarsAndrew LincolnNorman ReedusMelissa McBrideSheriff Deputy Rick Grimes wakes up from a coma to learn the world is in ruins and must lead a group of survivors to stay alive.
- CreatorShonda RhimesMichelle LirtzmanStarsEllen PompeoChandra WilsonJames Pickens Jr.A drama centered on the personal and professional lives of five surgical interns and their supervisors.
- CreatorKevin WilliamsonStarsDylan McDermottMaggie QVictor RasukA team of detectives investigates stalkers in Los Angeles.
- CreatorDan BucatinskyLisa KudrowDon RoosStarsLisa KudrowDan BucatinskyJennifer Elise CoxAfter quitting her job in finance under dubious circumstances, the affluent and self-interested Fiona Wallice tries her hand at therapy - offering clients 3-minute sessions over the Internet in hopes of weeding out any unnecessary emotion.
- CreatorBruno HellerStarsSimon BakerRobin TunneyTim KangA famous "psychic" outs himself as a fake, and starts working as a consultant for the California Bureau of Investigation so he can find "Red John", the madman who killed his wife and daughter.
- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorAnthony E. ZuikerStarsWilliam PetersenLaurence FishburneTed DansonIn Las Vegas, a squad of forensic investigators are trained to solve crimes by meticulously examining the evidence. They employ advanced technology and their rationality to detect the perpetrators.
- CreatorAnn DonahueCarol MendelsohnAnthony E. ZuikerStarsDavid CarusoEmily ProcterAdam RodriguezAn elite unit, led by an ex-homicide cop, which is linked to the Miami-Dade Police Department, uses all possible resources and skills at their disposal to solve complex crimes in cross-cultural Miami.
- CreatorPaul T. ScheuringStarsDominic PurcellWentworth MillerAmaury NolascoA structural engineer installs himself in a prison he helped design, in order to save his falsely accused brother from a death sentence by breaking themselves out from the inside.
- CreatorBrad FalchukRyan MurphyHalley FeifferStarsLady GagaKathy BatesAngela BassettAn anthology series centering on different characters and locations, showcasing different aspects of horror.
- CreatorMike KelleyStarsMadeleine StoweEmily VanCampGabriel MannAn emotionally troubled young woman sets out to exact revenge against the people who wronged her father.