Dr. Venture and his family are in Mexico, where the boys get kidnapped by the Monarch's henchmen. Brock goes on a rampage to get them back and Dr. Venture wakes up in a bathtub of ice to find he has no kidneys.
Dubbed the Ninth Wonder of the World, Jonas Venture's space station, Gargantua-1, has developed a problem, and Dr. Thaddeus Venture must fix his father's creation.