The Most Memorable Female Villain

Since film business established in society as a cultural achievement, there were many bad male villains to push a story forward with shockingly bad deeds and conspiracies. Since then, some times women also lost their innocence on screen and rushed up the mountain of malignancy. Some of them did very well.

Which of these actresses performed the evil, mean, devious, despicable, malignant, or brutal character the best?

Discuss it here.