- Has starred in 5 movies based on H.P. Lovecraft stories.
- Auditioned for the role of Commander Riker on Star Trek: The Next Generation (1987). Although he did not get the role, Jonathan Frakes, who did get the role, remembered Combs when directing an episode of Star Trek: Deep Space Nine (1993) and cast him in a guest role in that episode. The producers liked his performance so much he was later cast in two different recurring roles on the show.
- Named "the first Lovecraftian actor" by fans of writer H.P. Lovecraft, for his frequent appearances in movies based on Lovecraft's writings (including a portrayal of Lovecraft himself, in Necronomicon: Book of Dead (1993)) and also for his involvement in other "HPL projects".
- Is one of only 6 actors - along with Jonathan Frakes, Brent Spiner, Marina Sirtis, Michael Dorn and Colm Meaney - to appear in the finales of two different "Star Trek" series (Star Trek: Deep Space Nine (1993) and Star Trek: Enterprise (2001)). He is also the only one who was not a regular on any "Star Trek" series and the only one to play different characters in each finale: Weyoun in the former and Shran in the latter.
- Is the only actor to appear in both House on Haunted Hill (1999) and Return to House on Haunted Hill (2007).
- Star Trek: Enterprise (2001) executive producer Manny Coto and writer Mike Sussman have both stated that had the show been renewed for a fifth season, Combs would have been made a regular cast member.
- In the episode of The 4400 (2004) entitled "Wake Up Call", he hands a character a book by H.P. Lovecraft called "At the Mountains of Madness". Combs is well known for playing various roles in Lovecraftian movies.
- Out of all the "Star Trek" characters he has played, Weyoun (the officious Vorta ambassador for the Dominion) is his personal favorite.
- Has played five different clones of the same character (Weyoun) on Star Trek: Deep Space Nine (1993); he also played two other roles on the show. Also played two roles (so far) on Star Trek: Enterprise (2001), an Andorian and a Ferengi.
- Is one of only two actors - along with Brian Markinson - to play two different, completely unrelated characters in a single episode of "Star Trek". He played Weyoun and Liquidator Brunt in the Star Trek: Deep Space Nine (1993) Season Seven episode "The Dogs of War".
- Is one of only 4 actors - along with J.G. Hertzler, Randy Oglesby and Thomas Kopache - to play seven different characters on "Star Trek." He played Tiron, Liquidator Brunt, Weyoun and Officer Kevin Mulcahey in Star Trek: Deep Space Nine (1993), Penk in Star Trek: Voyager (1995) and Command Shran and Krem in Star Trek: Enterprise (2001).
- Is one of only 6 actors - along with Marc Alaimo, Rosalind Chao, John de Lancie, Jonathan Frakes and Tim Russ - to appear in ten different seasons of "Star Trek": Star Trek: Deep Space Nine (1993) Seasons Three through Seven, Star Trek: Voyager (1995) Season Six and Star Trek: Enterprise (2001) Seasons One through Four.
- In addition to his work on H.P.Lovecraft based projects, he voiced the part of H.P.Hatecraft on 2 episodes of Scooby Doo! Mystery Incorporated.
- Is one of only three actors - along with Gary Graham and Matt Winston - besides the regulars to appear in all four seasons of Star Trek: Enterprise (2001).
- Is the only actor to play three different recurring characters on "Star Trek": Weyoun and Liquidator Brunt in Star Trek: Deep Space Nine (1993) and Commander Shran in Star Trek: Enterprise (2001). He has also played Tiron and Officer Kevin Mulcahey in Star Trek: Deep Space Nine (1993), Penk in Star Trek: Voyager (1995) and Krem in Star Trek: Enterprise (2001).
- Has appeared with Brian Thompson in three different productions: Doctor Mordrid (1992), Star Trek: Deep Space Nine (1993) and Star Trek: Enterprise (2001).
- Attended and graduated from the University of Washington School of Drama.
- Is the only actor to appear in both of the last new "Star Trek" episodes to air before the deaths of Star Trek (1966) cast members DeForest Kelley and James Doohan respectively: the Star Trek: Deep Space Nine (1993) series finale "What You Leave Behind: Part 2" (which originally aired on June 2, 1999, nine days before Kelley's death on June 11) and the Star Trek: Enterprise (2001) series finale "These Are The Voyages..." (which originally aired on May 13, 2005, over two months before Doohan's death on July 20).
- Father of Catherine Combs with his wife Alice Cadogan.
- Is one of only two actors - along with Vaughn Armstrong - to play three different characters in a single "Star Trek" season (Star Trek: Deep Space Nine (1993) Season 6).
- Attended and graduated from Lompoc High School in Lompoc, California in 1972.
- Has two daughters, Catherine Combs and Natalie Combs.
- (May 1-3, 2009) Attended FedCon 18 in Bonn, Germany, sporting a mustache for an upcoming movie.
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