- Has had problems with alcohol and decided to become sober after "one particular night of debauchery". She is an advocate of Alcoholics Anonymous.
- Was diagnosed with breast cancer in February 2004. She recovered the same year.
- Adopted a baby boy, and named him Anderson after her mother's maiden name. (December 2004)
- Won $250,000 for Project ALS on a 2001 celebrity episode of "Who Wants to Be a Millionaire?".
- She is one of the few actresses to ever sweep the top three television awards. In 2000, she received the Emmy Award for Outstanding Lead Actress in a Drama Series, The Golden Globe Award for Best Performance by an Actress in a Drama Series, and the SAG Award for Outstanding Performance by a Female Actor in a Drama Series, all in the same year for her performance as Carmela Soprano in the HBO series The Sopranos (1999).
- Adopted a baby girl from Florida and named her Macy (February 2008).
- Edie Falco's 22nd Screen Actors Guild 2016 nomination for "Female Actor in a Comedy Series" - Showtime's Nurse Jackie (2009) - makes Edie Falco the most nominated performer/actor in SAG Awards history.
- Was forced to vacate the role of Jenny in Broadway's "The Threepenny Opera" due to her commitments to The Sopranos (1999). She was replaced by Cyndi Lauper.
- In 2013, she teamed up with PETA in an ad urging parents to keep their children away from the circus.
- Was in a relationship with Stanley Tucci from April 2003 until March 2004. They met while working together on "Frankie and Johnny in the Claire De Lune" on Broadway.
- Edie graduated from the acting program at the State University of New York at Purchase. After graduation, she worked as a clown and other similar roles at weddings and birthday parties.
- Nominated for a 2011 Tony Award as Best Performance by a Featured Actress in a Play for "The House of Blue Leaves".
- Is the daughter of art director Frank Falco and actress Judith Anderson (Judith M. Anderson).
- Her uncle is renowned fiction writer Ed Falco, who teaches at Virginia Polytechnic Institute and State University.
- Her father, Frank Falco, was of Italian descent, and her mother, Judith Anderson, had Swedish, English, and Cornish ancestry.
- Nominated for the 2018 Emmy Award in the Lead Actress in a Limited Series or Movie category for her role as Leslie Abramson in Law & Order True Crime (2017), but lost to Regina King from Seven Seconds (2018).
- Has a dog named Marley.
- Graduated from SUNY Purchase whose alumni are known collectively as "The Purchase Mafia".
- One of her earlier roles was in "The King's Creampuffs" at the age of 6.
- Was once mistaken for actress Felicity Huffman at Disney World, Florida.
- Edie played a bus passenger sitting across from Louis Winthorpe III (Dan Ackroyd) in "Trading Places" (1983).
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