- Actress Charlotte Rae (Mrs. Garrett) discovered Cohn and also named her character Natalie on The Facts of Life (1979). Rae met Cohn after she and the show's producers noticed her entertaining a group of friends at Harvard-Westlake School in Los Angeles, where they had gone to research and observe.
- Member of the board of directors of weSPARK, a cancer survivor organization founded by actress Wendie Jo Sperber.
- When she was on "The Facts of Life" for 9 years, the producers wouldn't let her audition for film roles, such as for St. Elmo's Fire (1985) in 1984. There was a wide gap between television and film actors at the time, until Michael J. Fox changed it when he starred in the hit film Back to the Future (1985) while simultaneously starring in the hit TV series "Family Ties". Mindy said Mare Winningham ended up getting the role in "St. Elmo's Fire" and that she did a great job in it.
- Graduated from Loyola Marymount in 1995 with a degree in sociology.
- Keeps in touch with her The Facts of Life (1979) co-star Kim Fields.
- In 2012, she candidly told Andy Cohen on his show "Watch What Happens Live" that "Facts of Life" jumped the shark a few times, meaning that the show veered off its natural path and declined in quality. She specifically mentioned when the store "Edna's Edibles" was burned down only to open another store called "Over Our Heads" at the beginning of the 1985-1986 season.
- Is the only one of the four 'Facts of Life' girls, who has never married nor had any children.
- Friends with Helen Hunt.
- Ranked #43 in VH1's list of the "100 Greatest Kid Stars".
- Was parodied in the TV show Clerks (2000).
- Best known by the public for her role as Natalie Green on The Facts of Life (1979).
- Was among the guests at Justine Bateman's 17th birthday party.
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