- Engaged to actress Nanda Karnataki at the time of his death.
- Son of Kikubhai Desai
- Elder brother of Subhash Desai
- Father of Ketan Desai
- He mostly directed for Bollywood legend Amitabh Bachchan, for whom he produced lots of hits.
- His popular theme was "lost and found" as in most of his superhit movies he had applied that type of theme.
- Emraan Hashmi's great grandfather(Grandmother Poornima's father)Ram Sheshadri Ayengar was a book keeper and accountant at Mammohan Desai's father, Kikubhai Desai's office.
- Directed Naami Chor when it was titled Phool Aur Kaante. He left the film after a fight with producer Kamal Mehra.
- There is a shelved film "Chhoti Si Duniya" that was being made in 1963. Starring Raj Kapoor and Nutan. It was being directed by Manmohan Desai. It got shelved when the financiers backed out .
- Nephew Pradeep Desai worked in the film Amar Akbar Anthony. Twenty-two-year old rookie film producer Pradeep Desai is embarking on a project which would daunt even old hands at the game. He is producing a film based on the lives of Billa and Ranga. Amol Palekar will take the part of Billa, and Mithun Chakravarty will star as Ranga. The subject is so "topical" that the Censor Board has advised the young producer not to go ahead with the film. If he does, he could lay himself wide open to a contempt of court, because Billa and Ranga have yet to be tried. Desai was deeply impressed by the movie, Helter Skelter, based on the Sharon Tate murders. Said Desai, "My film is going to be realistic. No running around trees, and no music." The film will be released only after the Billa-Ranga case is decided.
- Nephew is assistant director, special effects technician (Danny Desai ('Subash Desai' son). Danny Desai is now a pilot.
- Launched a film titled "Love Birds" with Kumar Gaurav in 1983. It was to be a Hindi and English bilingual film. He decided to shelve it. He later revived the film with Jugal Hansraj and Pratibha Sinha ( Who replaced Shabana Dutt). The title "Sweetheart" was also registered. After much thought they finally decided to make the film as Anmol with Rishi and Manisha.
- He has no daughters.
- Manmohan Desai was planning on a film titled "Construction Rani" starring Rati Agnihothri. This was in 1983. The film was to be made in 5 different languages. The project fizzled out.
- In 1988, Manmohan Desai and Ketan Desai launched "Gundaraj" to be written and directed and N.Chandra. The film got shelved.
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