- Has two children with her ex-husband Kelsey Grammer - a daughter Mason Olivia Grammer (b. October 24, 2001) and a son Jude Gordon Grammer (b. August 28, 2004). Both of her children were born via a surrogate mother.
- Former Playboy model.
- Was an MTV dancer.
- (October 20, 2018) Married her boyfriend of 2 years David C. Meyer, a lawyer, at a private beach club in Hawaii. Grammer's friends Teddi Mellencamp Arroyave, Dorit Kemsley, Lisa Rinna and Kyle Richards attended the ceremony when Richards also served as a bridesmaid. Grammer's daughter Mason was a bridesmaid when son Jude walked his mom down the aisle. Grammer began dating Meyer in 2016 and got engaged the following year.
- On October 11, 2013, Grammer underwent a radical hysterectomy after she was diagnosed with stage II endometrial cancer. On December 14, 2017, it was reported that she was diagnosed with Squamous Cell Carcinoma and she underwent a surgery recently to remove cancer cells. She is currently in remission.
- Ex-step-mother of Spencer Grammer.
- Grammer was diagnosed with irritable bowel syndrome in 1996, and has been featured in a Public Service Announcement to raise awareness of the disorder.
- Ex-stepmother of Spencer Grammer and Greer Grammer.
- Has a brother named Joseph (b. 1970).
- Has two step-sons.
- Born on the same day as actress Kristen Cloke.
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