- Melissa's maternal grandmother's sister was a successful Ziegfeld Follies Girl, discovered by Ziegfeld himself while she was waiting tables in Manhattan. Melissa's maternal grandmother came to Manhattan from Italy to be a professional opera singer. She was a lyric soprano.
- Melissa's father was a child prodigy on the piano, and continues to perform classical concerts at Juilliard to this day.
- Melissa met her husband, Patrick McEnroe, when she was in kindergarten. He was her older brother's (guitarist Mike Errico) best friend.
- Older brother, Mike Errico, is a singer/songwriter signed to "Hybrid Records"; Mike plays numerous solo acoustic guitar gigs in the NYC area.
- Daughter Vicoria Penny McEnroe was born in 2006.
- Announced that she and her husband, Patrick McEnroe, are expecting twins. [August 2008].
- Twin daughters, Diana and Juliette, born November 19, 2008.
- Sister-in-law of John McEnroe and Patty Smyth.
- Was nominated for Broadway's 2003 Tony Award as Best Actress (Musical) for "Amour."
- Melissa Errico was an acting and dance student of Broadway, film and television actor Michael Blevins, in her early career.
- Went to preschool with Broadway and film actress Melissa Errico. They became best friends and to this day they stay in touch.
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