- College roommate of George Lucas.
- John Travolta recommend him to direct Grease (1978) after having worked with him on The Boy in the Plastic Bubble (1976).
- His house used as "Jennifer's" in the movie "Scream 3". (2000)
- He was originally going to direct Muppets from Space (1999) but was dropped before production began.
- Older brother of Jeffrey Kleiser.
- He has directed two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Peege (1973) and Grease (1978).
- He turned down an offer to direct Blade Runner (1982) and was considered at one point to direct Flashdance (1983), The King of Comedy (1982), and Splash (1983). He was also attached to direct Annie (1982) before a dispute between Columbia Pictures' then-president Frank Price and him over the length of The Blue Lagoon (1980) forced him out of the project.
- Has tried for years to develop an adaptation to the screen of Tanith Lee's sci-fi romance novel "The Silver Metal Lover.".
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