- After his terrifying turn as "Buffalo Bill" in The Silence of the Lambs (1991), he's had some trouble getting parts other than sadistic psychopaths. He generally tries to choose parts more along the lines of ordinary family men and unfriendly co-workers to get away from the creepy shadow of "Buffalo Bill".
- The voice of Chris Griffin in Family Guy (1999) is based on him.
- While filming The Silence of the Lambs (1991), he and Brooke Smith, who played his hostage, became close friends due to having so many scenes together without any other cast members. Consequently, costar Jodie Foster began referring to Smith as "Patricia Hearst", a reference to the heiress who was abducted by a domestic terrorist organization in 1974 and eventually turned to the side of her captors.
- Has been friends with Sam Shepard and William Petersen since their early theater collaborations in the late 1970s.
- He was nominated for a 1996 Joseph Jefferson Award for Actor in a Supporting Role in a Play for "Buried Child" at the Steppenwolf Theatre Company in Chicago, Illinois.
- Ted and his Silence of the Lambs co-star, Scott Glenn, have both portrayed America's first man in space, Alan Shepard; Levine in the Tom Hanks-produced HBO mini series "From the Earth to the Moon," and Glenn in the 1984 Philip Kaufman film "The Right Stuff.".
- His father was of Russian Jewish descent. His mother had English ancestry.
- After appearing in The Silence of the Lambs (1991), he appeared in Heat (1995), which was directed by Manhunter (1986) director Michael Mann and featured Manhunter villain Tom Noonan.
- Has a daughter named Melissa (b. 1976) and a son named Mac (b. 1988) with different women.
- Has worked with both Clarice Starlings. He appeared in The Silence of the Lambs (1991) with Jodie Foster and, ten years later, he appeared in Evolution (2001) with Julianne Moore, who played Clarice Starling earlier that year in Hannibal (2001).
- Has worked with two Jack Crawfords. Prior to appearing in The Silence of the Lambs (1991) with Scott Glenn, he appeared in the television series Crime Story (1986), produced by Michael Mann and starring Dennis Farina, who played Jack Crawford in Manhunter (1986). Also featured in this series was Stephen Lang, who played Freddy Lounds in Manhunter (1986).
- Starred in a movie called Ellen Foster (1997). He also costarred with Jodie Foster in The Silence of the Lambs (1991). The one scene that they had together was when Buffalo Bill had night vision goggles and was hunting her in his own house, was spoofed in Mr. Monk and the Blackout (2004)(#3.3).
- Over the years, he has co-starred with four actors from TV's Prison Break (2005) - with William Fichtner in Heat (1995), Dominic Purcell in Moby Dick (1998), Wade Williams in Ali (2001) and Paul Adelstein in Memoirs of a Geisha (2005).
- Like Sex and the City (1998) star Chris Noth ("Mr. Big"), he attended Marlboro College in Vermont for a time in the 1970s.
- Starred with Debra Monk in Ellen Foster (1997). He later starred as Captain Leland Stottlemeyer in Monk (2002).
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