- He allegedly cheated on his wife-to-be, actress Ali Landry Monteverde, one day before the wedding and after the wedding. He was caught by onlookers cheating at his bachelor party. This is why Ali Landry Monteverde got the marriage annulled.
- He is a talented drummer and played drums on the 80s show Kids Incorporated (1984).
- Before being cast in Saved by the Bell (1989), Lopez was a dancer.
- Auditioned to replace Bob Barker as host of The Price is Right (1972). (May 2007)
- He has played the same character (A.C. Slater) in four different series: Saved by the Bell (1989), Saved by the Bell: The College Years (1993), Saved by the Bell: The New Class (1993) and Robot Chicken (2001).
- His girlfriend, Courtney Lopez, gave birth to a girl, Gia Lopez (Gia Francesca Lopez), on September 11, 2010 in Burbank, California. Gia weighed in at 6 lb. 4 oz. Gia's godmother is Eva Longoria.
- Was an amateur wrestler while in high school, and was on his high school wrestling team.
- He is the son of Elvira Soledad Trasviña and Mario Alberto López Pérez. His father was born in Culiacán, Sinaloa, and his mother was born in Tijuana, Territorio Norte de Baja California, both in Mexico. A DNA test undertaken by the show Finding Your Roots with Henry Louis Gates, Jr. (2012) stated that his genetic ancestry is 56% European, 41% Indigenous American, and 3% Sub-Saharan African.
- Close friend of Eva Longoria since 1992.
- 1991 graduate of Chula Vista High School.
- Athletics aside, his true passion in life is dancing. He has aspirations of one day dancing at Radio City music hall in New York City.
- Mario first met Courtney Lopez in 2008 when he was doing the Broadway production of "A Chorus Line".
- His wife, Courtney Lopez, gave birth to their third child, a boy named Santino Rafael Lopez, in July 2019.
- Mario and his wife, Courtney Lopez, are expecting their third child [June 5, 2019].
- Mario Lopez was a state placewinner in California at 189 pounds in 1990, contrary to popular belief, he was not a state champion. He ended up taking 7th Place at the California State High School tournament as a senior.
- On March 2, 1991 Lopez won a 3-1 decision over David Joe Harris of Carlsbad at the University of Pacific, Stockton to finish seventh in the 160 pound class at the CIF San Diego Section State Wrestling Meet. He won 6 of 8 matches at the tournament and finished his senior season with a 29-3 record for coach Art Stone.
- Ran in the 2011 New York City Marathon.
- Has a younger sister, Marissa Lopez, who is married to ex-Houston Texans linebacker Kailee Wong.
- Release of his book, "Mud Tacos", by Mario and his sister, Marissa Lopez Wong. (October 2009)
- Briefly worked at Coggin Honda in Orlando, Florida.
- (January 18, 2012) Engaged to Courtney Lopez.
- Mario and his wife, Courtney Lopez, are expecting their second child [April 13, 2013].
- Currently works as a Morning DJ for Hot 92 Jamz Radio Station in Southern California. (May 2005)
- His wife, Courtney Lopez, gave birth to their second child, a boy named Dominic Lopez, born on September 9, 2013.
- Mario and his girlfriend, Courtney Lopez, are expecting their first child in the Fall of 2010 [March 10, 2010].
- Proposed to actress/model Ali Landry Monteverde in summer 2003.
- Currently starring in the Broadway revival of "A Chorus Line", in the role of "Zach"; at the Gerald Schoenfeld Theater (May 2008)
- Currently working on the project "The Mangina Monologues" the male version of the famous "Vagina Monologues". (May 2005)
- Release of his book, "Mario Lopez's Knockout Fitness" by Mario with Jeff O'Connell. (May 2008)
- Became the 2008 bachelor of the year. (June 2008)
- Currently celebrity team captain of the "LA Riot" on American TV Show Extreme Dodgeball (2004). (November 2005)
- Release of his book, "Extra Lean". (May 2010)
- Appeared in an infomercial, hosted by Kim Kardashian, Khloé Kardashian and Kourtney Kardashian, for their "Perfect Skin" skin care system. (2010)
- Signed a deal with Celsius, a popular calorie-burning drink, to be their spokesman in 2010 [March 10, 2010].
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