- Is fluent in French.
- She was Stefano Accorsi's girlfriend until 2001.
- Daughter of actors Vittorio Mezzogiorno and Cecilia Sacchi.
- She worked in Paris for two years at the Peter Brook Workshop (Le Centre International de Créations Théatrales).
- Made her film debut in Il viaggio della sposa (1997), becoming Italy's most promising younger actress.
- Wanted to become a ballerina, so she studied dancing for 13 years.
- Has two tattoos on the inner side of her ankles: a "V", the initial letter of her father's name, and the scorpion zodiac sign.
- Her surname means "midday" in Italian.
- Made her stage debut as Ophelia in Peter Brook's "Qui est là" (1995).
- Lives in Rome, Milan and Paris.
- Was engaged to Daniele Anzellotti.
- Welcomed her children, twin sons Zeno and Leone. (August 26, 2011).
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