- Nuclear physicist. Member of team that developed atomic bomb.
- Is portrayed by Sam Waterston in Oppenheimer (1980), Dwight Schultz in Fat Man and Little Boy (1989), Hume Cronyn in "The Beginning Or The End", David Strathairn in "Day One" and Cillian Murphy in Oppenheimer (2023).
- Mentioned in the lyrics of the Sting song "Russians": "How can I save my little boy from Oppenheimer's deadly toy?".
- Director of Los Alamos National Laboratory, Los Alamos, New Mexico, 1943-1945.
- Older brother of fellow particle physicist and Manhattan Project scientist, Frank Oppenheimer, whose career was also cut short as a target in the Second Red Scare known as McCarthyism.
- Mentioned (though not by name) in the song "Manhattan Project" by Rush.
- Third cousin of actor Alan Oppenheimer, popular for, among many other achievements, as the voice of the character Skeletor from the "He-Man and The Masters of the Universe" animated series.
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