- Has suffered severe allergic reactions resulting in hives that hospitalized her. She had them at age seven, 14 and 21 and has had to use prednisone to control the severe bouts.
- Children with husband Garry Trudeau: Twins Ross and Rachel (born in 1983), and Thomas (born in 1986)
- In 1990 she was chosen by People magazine as one of the 50 Most Beautiful People in the world.
- Her father, Richard, was a milk salesman in Bloomington, IN. Her mother, Mary, was diagnosed with ovarian cancer when Jane was only 13. After that, her mother had a series of heart attacks and strokes before her death.
- Attended Indiana University in Bloomington, IN.
- She and her sister, Ann Pauley, are best friends. Anne, like Jane, also graduated from Indiana University.
- She was diagnosed with bipolar disorder at the age of 50.
- Presbyterian.
- Had many cats as pets when she was little.
- Has been prescribed lithium to treat her bipolar illness.
- Graduated from Warren Central High School in Indianapolis, IN, the same high school as former NFL quarterback Jeff George..
- As of September 2004 was hosting The Jane Pauley Show (2004).
- Inducted into the Connecticut Women's Hall of Fame in 2016.
- Received honorary doctorate from Trinity College in 1998.
- Is a sister of Kappa Kappa Gamma
- Graduated from the same high school as former NFL Quarterback Jeff George.
- Born on the same day as actor John Candy.
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