- He was still credited as executive producer on The Simpsons (1989), despite not having worked on the show since 1993. He estimated his severance deal earned him around $10 million a year.
- In late 2012, Sam Simon was diagnosed with terminal stage 4 colon cancer, which then metastasized to his kidneys, liver, brain and stomach.
- Was a "Phone-a-friend" lifeline for both Drew Carey and Norm MacDonald when they appeared on Who Wants to Be a Millionaire (1999).
- Former brother-in-law of Meg Tilly, Steve Tilly and Rebecca Tilly.
- Managed WBO world heavyweight boxing champion Lamon Brewster.
- Was close friends with Howard Stern's hair stylist and sidekick Ralph Cirella.
- Mother Joan owned the Functional Art Gallery in Venice, California. Father Arthur was a UCLA basketball player who lost a leg in World War II. He owned a Los Angeles factory that made a women's line of designer knockoff clothes called Sun and Sand.
- After college graduation he landed a job drawing storyboards for Filmation.
- Graduated from Stanford University in 1977.
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