- Is fifteen minutes younger than his twin, Dylan.
- Graduated from Laurel Springs School in June of 2010 and later went on to attend and graduate from NYU's Gallatin School of Individualized Study with a degree in archaeology.
- Is an active travel and fashion photographer.
- Worked for Meltdown Comics in Los Angeles, California where he is the official event photographer. (April 2011)
- Although born in Italy, is not of Italian descent. Cole's American parents moved back to their native California four months after Dylan and Cole were born. His ancestry is English, Scottish, German, and one eighth Danish.
- He has been snowboarding since he was 4 years old.
- Currently in Los Angeles. Cole has decided to take the NYU Gallatin course instead of his previous choices. Gallatin gives students the opportunity to design a program of study tailored to their own needs and interests. (February 2011)
- Attended NYU at the same time as his Riverdale (2017) co-star, Camila Mendes, although they did not know each other while attending.
- Dyed his hair black for the role of Jughead Jones in Riverdale (2017), and also Will Newman in Five Feet Apart. His natural hair color is blond.
- Started studying at NYU's Gallatin School of Individualized Study. (September 2011)
- Cole stars as Jughead on Riverdale, a show based on the Archie comics. As a child, he appeared on Friends, portraying Ross Geller's son Ben in seven episodes. In the first of those episodes, an alternate reality from the usual Friends storylines, Chandler is a writer and sells a story to Archie Comics.
- His favorite movie is Harold and Maude (1971).
- Twin brother of Dylan Sprouse.
- His parents are Matthew and Melanie Sprouse.
- Nominated for MVP (Most Valuable Player) for week 6 for the Disney Channel Games 2007 for Super Soccer for leading the blue team but didn't win. He lost to his The Suite Life of Zack and Cody co-star Ashley Tisdale, who was on the red team.
- Brother-in-law of Barbara Palvin.
- Is a smoker.
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