- He was born with anosmia, which means he can't smell. It affects his sense of taste since smell and taste are so closely connected.
- Co-starred with Jennifer Aniston in five movies: The Bounty Hunter (2010), Horrible Bosses (2011), We're the Millers (2013), Horrible Bosses 2 (2014) and Mother's Day (2016).
- His maternal uncle is actor George Wendt. His maternal great-grandfather was photographer Tom Howard.
- (October 11, 2016) Welcomed daughter, Daisy Sudeikis, with his then-fiancée Olivia Wilde.
- (October 2016 - December 2016) He played John Keating in the off-Broadway theatre production of Dead Poets Society (1989) at the Classic Stage Company in New York City.
- (April 20, 2014) Welcomed son, Otis Sudeikis, with his then-fiancée Olivia Wilde.
- He became the voice of advertisements for the Applebee's casual dining chain that began running in 2012. A scene from Hall Pass (2011) took place at an Applebee's restaurant.
- He was a basketball player for the NBA Celebrity All-Star Game in 2011 and 2016.
- His last name, Sudeikis, is pronounced su-day-kiss.
- He was a regular cast member for The Second City Las Vegas.
- He frequently performs at the Upright Citizens Brigade Theatre's weekly improv show ASSSCAT 3000 in New York City.
- He is of a Lithuanian and Irish ancestry on his father's side of the family, and, a German and Irish ancestry on his mother's side.
- Ranked #73 of the "100 Sexiest Men 2017" list for Glamour UK.
- Co-starred with Bill Hader and Joe Lo Truglio in the Lorne Michaels-produced web-series "The Line on Crackle.".
- Brother of Kristen Sudeikis and Lindsay Sudeikis.
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