- Best known for her work on Mad TV (1995) for her dead-pan impressions of Anna Nicole Smith and Reba McEntire. Other Madtv characters she played include: "Dot", "Dr. Kylie Johnson", "Dorothy Lanier", "Angela Wright", and "Mrs. Campbell". "Mrs. Campbell" is based on Weir's real life Texan grandmother.
- She writes most of her character sketches
- Is still part of the "Second City Improv Comedy Group" and travels to Chicago to perform whenever she can.
- Born on the same day and in the same state as Anna Nicole Smith, the subject of one of her most well known impersonations.
- Completed the 2004 Honolulu Marathon in 5:13.59.
- Although most of Weir's characters were made up by her imagination, Mrs. Campbell is based on Weir's real life Texan grandmother.
- Her name is not misspelled yet is unique because of the apparent missing "a".
- She was nominated for a 2000 Joseph Jefferson Award for Actress in a Revue for her performance at Second City Theatre in Chicago, Illinois.
- When Mad TV (1995) was on hiatus for the season, Weir performed improv across the United States with her husband, Robert Dassie. (June 2004)
- Attended Odessa Junior College in Odessa, Texas
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