Is a professional boxer. And former world champion.
Is of Native American descent (specifically Cherokee, Nipmuc, and Seaconke Wampanoag) and Cape Verdean ancestry.
Active supporter of the Missing and Murdered Indigenous Women and Girls (MMIWG) movement.
Is a former world champion in two weight classes, having held the WBC female middleweight title in 2016 and the WBA, WBO, and IBO female light welterweight titles between 2020 and 2022.
Started boxing at 14.
Reis' boxing nickname is that of K.O. Mequinonoag, pulled from the name her mother gave her, which is "the medicine woman of our Seaconke Wampanoag tribe," according to Reis.