- Grandson of John Wayne
- Brendan Wayne worked on every single episode of season one of The Mandalorian according to Vulture Article, Meet the Man Beneath the Mandalorian's Armor (December 2019).
- Son of Toni Wayne
- Performed all of his own stunts in Cowboys & Aliens (2011).
- Great-nephew of Robert E. Morrison
- Brendan Wayne and his wife, Sara Arrington have both worked with Jon Favreau before The Mandalorian. Brendan on Cowboys & Aliens and Sara on The Jungle Book.
- The Mandalorian is often called a "space western" and has influences from Sergio Leone's "Dollars" trilogy. One of the cast members, Brendan Wayne, is the grandson of legendary actor John Wayne, who was known for his frequent appearances in westerns.
- Great-nephew of Lou LaCava
- Attended The American Academy of Dramatic Arts in Pasadena, California.
- According to Vulture Article, Meet the Man Beneath the Mandalorian's Armor (2019) Brendan Wayne worked on and appears in every episode of Season One.
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